3TC
3TC Brand names, 3TC Analogs
3TC Brand Names Mixture
- Combivir (Lamivudine + Zidovudine)
- Kivexa (Abacavir (Abacavir Sulfate) + Lamivudine)
- Trizivir (Abacavir (Abacavir Sulfate) + Lamivudine + Zidovudine)
3TC Chemical_Formula
C8H11N3O3S
3TC RX_link
http://www.rxlist.com/cgi/generic3/lamivudine.htm
3TC fda sheet
3TC msds (material safety sheet)
3TC Synthesis Reference
No information avaliable
3TC Molecular Weight
229.257 g/mol
3TC Melting Point
160-162 oC
3TC H2O Solubility
70 mg/ml
3TC State
Solid
3TC LogP
No information avaliable
3TC Dosage Forms
Solution; Tablet
3TC Indication
For the treatment of HIV infection and chronic hepatitis B (HBV).
3TC Pharmacology
Lamivudine is a nucleoside reverse transcriptase inhibitor (NRTI) with activity against Human Immunodeficiency Virus Type 1 (HIV-1) and hepatitis B (HBV). Lamivudine is phosphorylated to active metabolites that compete for incorporation into viral DNA. They inhibit the HIV reverse transcriptase enzyme competitively and act as a chain terminator of DNA synthesis. The lack of a 3'-OH group in the incorporated nucleoside analogue prevents the formation of the 5' to 3' phosphodiester linkage essential for DNA chain elongation, and therefore, the viral DNA growth is terminated.
3TC Absorption
Lamivudine was rapidly absorbed after oral administration in HIV-infected patients. Absolute bioavailability in adults is 86% ± 16% for the tablet and 87% ± 13% for the oral solution.
3TC side effects and Toxicity
No information avaliable
3TC Patient Information
3TC Organisms Affected
Human immunodeficiency virus and Hepatitis B virus
