3TC en es it fr

3TC Brand names, 3TC Analogs

3TC Brand Names Mixture

  • Combivir (Lamivudine + Zidovudine)
  • Kivexa (Abacavir (Abacavir Sulfate) + Lamivudine)
  • Trizivir (Abacavir (Abacavir Sulfate) + Lamivudine + Zidovudine)

3TC Chemical_Formula


3TC RX_link


3TC fda sheet


3TC msds (material safety sheet)


3TC Synthesis Reference

No information avaliable

3TC Molecular Weight

229.257 g/mol

3TC Melting Point

160-162 oC

3TC H2O Solubility

70 mg/ml

3TC State


3TC LogP

No information avaliable

3TC Dosage Forms

Solution; Tablet

3TC Indication

For the treatment of HIV infection and chronic hepatitis B (HBV).

3TC Pharmacology

Lamivudine is a nucleoside reverse transcriptase inhibitor (NRTI) with activity against Human Immunodeficiency Virus Type 1 (HIV-1) and hepatitis B (HBV). Lamivudine is phosphorylated to active metabolites that compete for incorporation into viral DNA. They inhibit the HIV reverse transcriptase enzyme competitively and act as a chain terminator of DNA synthesis. The lack of a 3'-OH group in the incorporated nucleoside analogue prevents the formation of the 5' to 3' phosphodiester linkage essential for DNA chain elongation, and therefore, the viral DNA growth is terminated.

3TC Absorption

Lamivudine was rapidly absorbed after oral administration in HIV-infected patients. Absolute bioavailability in adults is 86% ± 16% for the tablet and 87% ± 13% for the oral solution.

3TC side effects and Toxicity

No information avaliable

3TC Patient Information

3TC Organisms Affected

Human immunodeficiency virus and Hepatitis B virus