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Combivir Brand names, Combivir Analogs

Combivir Brand Names Mixture

  • Combivir (Lamivudine + Zidovudine)
  • Kivexa (Abacavir (Abacavir Sulfate) + Lamivudine)
  • Trizivir (Abacavir (Abacavir Sulfate) + Lamivudine + Zidovudine)

Combivir Chemical_Formula

C8H11N3O3S

Combivir RX_link

http://www.rxlist.com/cgi/generic3/lamivudine.htm

Combivir fda sheet

Combivir FDA

Combivir msds (material safety sheet)

Combivir MSDS

Combivir Synthesis Reference

No information avaliable

Combivir Molecular Weight

229.257 g/mol

Combivir Melting Point

160-162 oC

Combivir H2O Solubility

70 mg/ml

Combivir State

Solid

Combivir LogP

No information avaliable

Combivir Dosage Forms

Solution; Tablet

Combivir Indication

For the treatment of HIV infection and chronic hepatitis B (HBV).

Combivir Pharmacology

Lamivudine is a nucleoside reverse transcriptase inhibitor (NRTI) with activity against Human Immunodeficiency Virus Type 1 (HIV-1) and hepatitis B (HBV). Lamivudine is phosphorylated to active metabolites that compete for incorporation into viral DNA. They inhibit the HIV reverse transcriptase enzyme competitively and act as a chain terminator of DNA synthesis. The lack of a 3'-OH group in the incorporated nucleoside analogue prevents the formation of the 5' to 3' phosphodiester linkage essential for DNA chain elongation, and therefore, the viral DNA growth is terminated.

Combivir Absorption

Lamivudine was rapidly absorbed after oral administration in HIV-infected patients. Absolute bioavailability in adults is 86% ± 16% for the tablet and 87% ± 13% for the oral solution.

Combivir side effects and Toxicity

No information avaliable

Combivir Patient Information

Combivir Organisms Affected

Human immunodeficiency virus and Hepatitis B virus