Ibilex
Brand names,
Ibilex
Analogs
Ibilex
Brand Names Mixture
Ibilex
Chemical_Formula
C16H17N3O4S
Ibilex
RX_link
http://www.rxlist.com/cgi/generic/cephalex.htm
Ibilex
fda sheet
Ibilex
msds (material safety sheet)
Ibilex
Synthesis Reference
R. B. Morin, B. G. Jackson, U.S. Pat. 3,275,626,861 (1966,1970)
Ibilex
Molecular Weight
347.39 g/mol
Ibilex
Melting Point
326.8oC
Ibilex
H2O Solubility
1789 mg/L
Ibilex
State
Solid
Ibilex
LogP
0.019
Ibilex
Dosage Forms
Capsules (containing cephalexin monohydrate equivalent to 250 mg or 500 mg cephalexin); Tablet (containing cephalexin monohydrate equivalent to 250 mg or 500 mg of cephalexin); Suspension
Ibilex
Indication
For the treatment of respiratory tract infections caused by Streptococcus pneumoniae and Streptococcus pyogenes; otitis media due to Streptococcus pneumoniae, Haemophilus influenzae, Staphylococcus aureus, Streptococcus pyogenes, and Moraxella catarrhalis; skin and skin structure infections caused by Staphylococcus aureus and/or Streptococcus pyogenes; bone infections caused by Staphylococcus aureus and/or Proteus mirabilis; genitourinary tract infections, including acute prostatitis, caused by Escherichia coli, Proteus mirabilis, and Klebsiella pneumoniae.
Ibilex
Pharmacology
Cephalexin (also called Cefalexin) is a first generation cephalosporin antibiotic. It is one of the most widely prescribed antibiotics, often used for the treatment of superficial infections that result as complications of minor wounds or lacerations. It is effective against most gram-positive bacteria.
Ibilex
Absorption
Well absorbed from the gastrointestinal tract
Ibilex
side effects and Toxicity
Symptoms of overdose include blood in the urine, diarrhea, nausea, upper abdominal pain, and vomiting. The oral median lethal dose of cephalexin in rats is >5000 mg/kg.
Ibilex
Patient Information
Patients should be counseled that antibacterial drugs including Keflex should only be used to treat bacterial
infections. They do not treat viral infections (e.g., the common cold). When Keflex is prescribed to treat a
bacterial infection, patients should be told that although it is common to feel better early in the course of
therapy, the medication should be taken exactly as directed. Skipping doses or not completing the full course of
therapy may (1) decrease the effectiveness of the immediate treatment and (2) increase the likelihood that bacteria
will develop resistance and will not be treatable by Keflex or other antibacterial drugs in the future.
Ibilex
Organisms Affected
Enteric bacteria and other eubacteria