Hydromorphone en es it fr

Hydromorphone Brand names, Hydromorphone Analogs

Hydromorphone Brand Names Mixture

  • No information avaliable

Hydromorphone Chemical_Formula


Hydromorphone RX_link


Hydromorphone fda sheet

Hydromorphone FDA

Hydromorphone msds (material safety sheet)

Hydromorphone MSDS

Hydromorphone Synthesis Reference

No information avaliable

Hydromorphone Molecular Weight

285.338 g/mol

Hydromorphone Melting Point

266-267 oC

Hydromorphone H2O Solubility

No information avaliable

Hydromorphone State


Hydromorphone LogP

1.28 (Roy, SD; Flynn, GL Pharm. Res. 5:580 (1988))

Hydromorphone Dosage Forms

Capsule (controlled-delivery); Solution; Tablet

Hydromorphone Indication

For the relief of moderate to severe pain such as that due to surgery, cancer, trauma/injury, burns, myocardial infarction and colic.

Hydromorphone Pharmacology

Hydromorphone is a hydrogenated ketone derivative of morphine that acts as a narcotic analgesic. It has a shorter duration of action than morphine. Hydromorphone is approximately 8 times more potent on a milligram basis than morphine. In addition, hydromorphone is better absorbed orally than is morphine. In clinical settings, Hydromorphone exerts its principal pharmacological effect on the central nervous system and gastrointestinal tract. Its primary actions of therapeutic value are analgesia and sedation. Hydromorphone appears to increase the patient's tolerance for pain and to decrease discomfort, although the presence of the pain itself may still be recognized. In addition to analgesia, alterations in mood, euphoria and dysphoria, and drowsiness commonly occur. Opioids also produce respiratory depression by direct action on brain stem respiratory centers.

Hydromorphone Absorption

Better absorbed orally than morphine

Hydromorphone side effects and Toxicity

Hydromorphone is a schedule II narcotic which can lead to physical dependence or addiction. High doses lead to respiratory depression, nausea, and vomiting. Overdoses lead to extreme somnolence progressing to stupor or coma, skeletal muscle flaccidity, cold and clammy skin, and sometimes bradycardia and hypotension. In severe overdosage, apnea, circulatory collapse, cardiac arrest and death may occur.

Hydromorphone Patient Information


Hydromorphone Organisms Affected

Humans and other mammals