Palladone en es it fr

Palladone Brand names, Palladone Analogs

Palladone Brand Names Mixture

  • No information avaliable

Palladone Chemical_Formula


Palladone RX_link

Palladone fda sheet

Palladone FDA

Palladone msds (material safety sheet)

Palladone MSDS

Palladone Synthesis Reference

No information avaliable

Palladone Molecular Weight

285.338 g/mol

Palladone Melting Point

266-267 oC

Palladone H2O Solubility

No information avaliable

Palladone State


Palladone LogP

1.28 (Roy, SD; Flynn, GL Pharm. Res. 5:580 (1988))

Palladone Dosage Forms

Capsule (controlled-delivery); Solution; Tablet

Palladone Indication

For the relief of moderate to severe pain such as that due to surgery, cancer, trauma/injury, burns, myocardial infarction and colic.

Palladone Pharmacology

Hydromorphone is a hydrogenated ketone derivative of morphine that acts as a narcotic analgesic. It has a shorter duration of action than morphine. Hydromorphone is approximately 8 times more potent on a milligram basis than morphine. In addition, hydromorphone is better absorbed orally than is morphine. In clinical settings, Hydromorphone exerts its principal pharmacological effect on the central nervous system and gastrointestinal tract. Its primary actions of therapeutic value are analgesia and sedation. Hydromorphone appears to increase the patient's tolerance for pain and to decrease discomfort, although the presence of the pain itself may still be recognized. In addition to analgesia, alterations in mood, euphoria and dysphoria, and drowsiness commonly occur. Opioids also produce respiratory depression by direct action on brain stem respiratory centers.

Palladone Absorption

Better absorbed orally than morphine

Palladone side effects and Toxicity

Hydromorphone is a schedule II narcotic which can lead to physical dependence or addiction. High doses lead to respiratory depression, nausea, and vomiting. Overdoses lead to extreme somnolence progressing to stupor or coma, skeletal muscle flaccidity, cold and clammy skin, and sometimes bradycardia and hypotension. In severe overdosage, apnea, circulatory collapse, cardiac arrest and death may occur.

Palladone Patient Information

Palladone Organisms Affected

Humans and other mammals