Dilaudid Oros
Brand names,
Dilaudid Oros
Analogs
Dilaudid Oros
Brand Names Mixture
Dilaudid Oros
Chemical_Formula
C17H19NO3
Dilaudid Oros
RX_link
http://www.rxlist.com/cgi/generic/hydromorphone.htm
Dilaudid Oros
fda sheet
Dilaudid Oros
msds (material safety sheet)
Dilaudid Oros
Synthesis Reference
No information avaliable
Dilaudid Oros
Molecular Weight
285.338 g/mol
Dilaudid Oros
Melting Point
266-267 oC
Dilaudid Oros
H2O Solubility
No information avaliable
Dilaudid Oros
State
Solid
Dilaudid Oros
LogP
1.28 (Roy, SD; Flynn, GL Pharm. Res. 5:580 (1988))
Dilaudid Oros
Dosage Forms
Capsule (controlled-delivery); Solution; Tablet
Dilaudid Oros
Indication
For the relief of moderate to severe pain such as that due to surgery, cancer, trauma/injury, burns, myocardial infarction and colic.
Dilaudid Oros
Pharmacology
Hydromorphone is a hydrogenated ketone derivative of morphine that acts as a narcotic analgesic. It has a shorter duration of action than morphine. Hydromorphone is approximately 8 times more potent on a milligram basis than morphine. In addition, hydromorphone is better absorbed orally than is morphine. In clinical settings, Hydromorphone exerts its principal pharmacological effect on the central nervous system and gastrointestinal tract. Its primary actions of therapeutic value are analgesia and sedation. Hydromorphone appears to increase the patient's tolerance for pain and to decrease discomfort, although the presence of the pain itself may still be recognized. In addition to analgesia, alterations in mood, euphoria and dysphoria, and drowsiness commonly occur. Opioids also produce respiratory depression by direct action on brain stem respiratory centers.
Dilaudid Oros
Absorption
Better absorbed orally than morphine
Dilaudid Oros
side effects and Toxicity
Hydromorphone is a schedule II narcotic which can lead to physical dependence or addiction. High doses lead to respiratory depression, nausea, and vomiting. Overdoses lead to extreme somnolence progressing to stupor or coma, skeletal muscle flaccidity, cold and clammy skin, and sometimes bradycardia and hypotension. In severe overdosage, apnea, circulatory collapse, cardiac arrest and death may occur.
Dilaudid Oros
Patient Information
http://www.drugs.com/cons/Hydroflumethiazide.html
Dilaudid Oros
Organisms Affected
Humans and other mammals