Dimorphone
Dimorphone Brand names, Dimorphone Analogs
- DiMo
- Dihydromorfinon
- Dihydromorfinon [Czech]
- Dihydromorphinone
- Dilaudid
- Dilaudid Oros
- Dilaudid-hp
- Dimorphone
- Hidromorfona [INN-Spanish]
- Hydromorfona [Spanish]
- Hydromorphon
- Hydromorphone HCL
- Hydromorphonum [INN-Latin]
- Hymorphan
- Idromorfone
- Idromorfone [DCIT]
- Laudacon
- Laudicon
- Morphinone, dihydro-
- Novolaudon
- Palladone
- Paramorphan
Dimorphone Brand Names Mixture
- No information avaliable
Dimorphone Chemical_Formula
C17H19NO3
Dimorphone RX_link
http://www.rxlist.com/cgi/generic/hydromorphone.htm
Dimorphone fda sheet
Dimorphone msds (material safety sheet)
Dimorphone Synthesis Reference
No information avaliable
Dimorphone Molecular Weight
285.338 g/mol
Dimorphone Melting Point
266-267 oC
Dimorphone H2O Solubility
No information avaliable
Dimorphone State
Solid
Dimorphone LogP
1.28 (Roy, SD; Flynn, GL Pharm. Res. 5:580 (1988))
Dimorphone Dosage Forms
Capsule (controlled-delivery); Solution; Tablet
Dimorphone Indication
For the relief of moderate to severe pain such as that due to surgery, cancer, trauma/injury, burns, myocardial infarction and colic.
Dimorphone Pharmacology
Hydromorphone is a hydrogenated ketone derivative of morphine that acts as a narcotic analgesic. It has a shorter duration of action than morphine. Hydromorphone is approximately 8 times more potent on a milligram basis than morphine. In addition, hydromorphone is better absorbed orally than is morphine. In clinical settings, Hydromorphone exerts its principal pharmacological effect on the central nervous system and gastrointestinal tract. Its primary actions of therapeutic value are analgesia and sedation. Hydromorphone appears to increase the patient's tolerance for pain and to decrease discomfort, although the presence of the pain itself may still be recognized. In addition to analgesia, alterations in mood, euphoria and dysphoria, and drowsiness commonly occur. Opioids also produce respiratory depression by direct action on brain stem respiratory centers.
Dimorphone Absorption
Better absorbed orally than morphine
Dimorphone side effects and Toxicity
Hydromorphone is a schedule II narcotic which can lead to physical dependence or addiction. High doses lead to respiratory depression, nausea, and vomiting. Overdoses lead to extreme somnolence progressing to stupor or coma, skeletal muscle flaccidity, cold and clammy skin, and sometimes bradycardia and hypotension. In severe overdosage, apnea, circulatory collapse, cardiac arrest and death may occur.
Dimorphone Patient Information
http://www.drugs.com/cons/Hydroflumethiazide.html
Dimorphone Organisms Affected
Humans and other mammals
