Laudacon
Brand names,
Laudacon
Analogs
Laudacon
Brand Names Mixture
Laudacon
Chemical_Formula
C17H19NO3
Laudacon
RX_link
http://www.rxlist.com/cgi/generic/hydromorphone.htm
Laudacon
fda sheet
Laudacon
msds (material safety sheet)
Laudacon
Synthesis Reference
No information avaliable
Laudacon
Molecular Weight
285.338 g/mol
Laudacon
Melting Point
266-267 oC
Laudacon
H2O Solubility
No information avaliable
Laudacon
State
Solid
Laudacon
LogP
1.28 (Roy, SD; Flynn, GL Pharm. Res. 5:580 (1988))
Laudacon
Dosage Forms
Capsule (controlled-delivery); Solution; Tablet
Laudacon
Indication
For the relief of moderate to severe pain such as that due to surgery, cancer, trauma/injury, burns, myocardial infarction and colic.
Laudacon
Pharmacology
Hydromorphone is a hydrogenated ketone derivative of morphine that acts as a narcotic analgesic. It has a shorter duration of action than morphine. Hydromorphone is approximately 8 times more potent on a milligram basis than morphine. In addition, hydromorphone is better absorbed orally than is morphine. In clinical settings, Hydromorphone exerts its principal pharmacological effect on the central nervous system and gastrointestinal tract. Its primary actions of therapeutic value are analgesia and sedation. Hydromorphone appears to increase the patient's tolerance for pain and to decrease discomfort, although the presence of the pain itself may still be recognized. In addition to analgesia, alterations in mood, euphoria and dysphoria, and drowsiness commonly occur. Opioids also produce respiratory depression by direct action on brain stem respiratory centers.
Laudacon
Absorption
Better absorbed orally than morphine
Laudacon
side effects and Toxicity
Hydromorphone is a schedule II narcotic which can lead to physical dependence or addiction. High doses lead to respiratory depression, nausea, and vomiting. Overdoses lead to extreme somnolence progressing to stupor or coma, skeletal muscle flaccidity, cold and clammy skin, and sometimes bradycardia and hypotension. In severe overdosage, apnea, circulatory collapse, cardiac arrest and death may occur.
Laudacon
Patient Information
http://www.drugs.com/cons/Hydroflumethiazide.html
Laudacon
Organisms Affected
Humans and other mammals