Hydromorphone HCL
Hydromorphone HCL Brand names, Hydromorphone HCL Analogs
- DiMo
- Dihydromorfinon
- Dihydromorfinon [Czech]
- Dihydromorphinone
- Dilaudid
- Dilaudid Oros
- Dilaudid-hp
- Dimorphone
- Hidromorfona [INN-Spanish]
- Hydromorfona [Spanish]
- Hydromorphon
- Hydromorphone HCL
- Hydromorphonum [INN-Latin]
- Hymorphan
- Idromorfone
- Idromorfone [DCIT]
- Laudacon
- Laudicon
- Morphinone, dihydro-
- Novolaudon
- Palladone
- Paramorphan
Hydromorphone HCL Brand Names Mixture
- No information avaliable
Hydromorphone HCL Chemical_Formula
C17H19NO3
Hydromorphone HCL RX_link
http://www.rxlist.com/cgi/generic/hydromorphone.htm
Hydromorphone HCL fda sheet
Hydromorphone HCL msds (material safety sheet)
Hydromorphone HCL Synthesis Reference
No information avaliable
Hydromorphone HCL Molecular Weight
285.338 g/mol
Hydromorphone HCL Melting Point
266-267 oC
Hydromorphone HCL H2O Solubility
No information avaliable
Hydromorphone HCL State
Solid
Hydromorphone HCL LogP
1.28 (Roy, SD; Flynn, GL Pharm. Res. 5:580 (1988))
Hydromorphone HCL Dosage Forms
Capsule (controlled-delivery); Solution; Tablet
Hydromorphone HCL Indication
For the relief of moderate to severe pain such as that due to surgery, cancer, trauma/injury, burns, myocardial infarction and colic.
Hydromorphone HCL Pharmacology
Hydromorphone is a hydrogenated ketone derivative of morphine that acts as a narcotic analgesic. It has a shorter duration of action than morphine. Hydromorphone is approximately 8 times more potent on a milligram basis than morphine. In addition, hydromorphone is better absorbed orally than is morphine. In clinical settings, Hydromorphone exerts its principal pharmacological effect on the central nervous system and gastrointestinal tract. Its primary actions of therapeutic value are analgesia and sedation. Hydromorphone appears to increase the patient's tolerance for pain and to decrease discomfort, although the presence of the pain itself may still be recognized. In addition to analgesia, alterations in mood, euphoria and dysphoria, and drowsiness commonly occur. Opioids also produce respiratory depression by direct action on brain stem respiratory centers.
Hydromorphone HCL Absorption
Better absorbed orally than morphine
Hydromorphone HCL side effects and Toxicity
Hydromorphone is a schedule II narcotic which can lead to physical dependence or addiction. High doses lead to respiratory depression, nausea, and vomiting. Overdoses lead to extreme somnolence progressing to stupor or coma, skeletal muscle flaccidity, cold and clammy skin, and sometimes bradycardia and hypotension. In severe overdosage, apnea, circulatory collapse, cardiac arrest and death may occur.
Hydromorphone HCL Patient Information
http://www.drugs.com/cons/Hydroflumethiazide.html
Hydromorphone HCL Organisms Affected
Humans and other mammals
