Hydromorphon
Hydromorphon Brand names, Hydromorphon Analogs
- DiMo
- Dihydromorfinon
- Dihydromorfinon [Czech]
- Dihydromorphinone
- Dilaudid
- Dilaudid Oros
- Dilaudid-hp
- Dimorphone
- Hidromorfona [INN-Spanish]
- Hydromorfona [Spanish]
- Hydromorphon
- Hydromorphone HCL
- Hydromorphonum [INN-Latin]
- Hymorphan
- Idromorfone
- Idromorfone [DCIT]
- Laudacon
- Laudicon
- Morphinone, dihydro-
- Novolaudon
- Palladone
- Paramorphan
Hydromorphon Brand Names Mixture
- No information avaliable
Hydromorphon Chemical_Formula
C17H19NO3
Hydromorphon RX_link
http://www.rxlist.com/cgi/generic/hydromorphone.htm
Hydromorphon fda sheet
Hydromorphon msds (material safety sheet)
Hydromorphon Synthesis Reference
No information avaliable
Hydromorphon Molecular Weight
285.338 g/mol
Hydromorphon Melting Point
266-267 oC
Hydromorphon H2O Solubility
No information avaliable
Hydromorphon State
Solid
Hydromorphon LogP
1.28 (Roy, SD; Flynn, GL Pharm. Res. 5:580 (1988))
Hydromorphon Dosage Forms
Capsule (controlled-delivery); Solution; Tablet
Hydromorphon Indication
For the relief of moderate to severe pain such as that due to surgery, cancer, trauma/injury, burns, myocardial infarction and colic.
Hydromorphon Pharmacology
Hydromorphone is a hydrogenated ketone derivative of morphine that acts as a narcotic analgesic. It has a shorter duration of action than morphine. Hydromorphone is approximately 8 times more potent on a milligram basis than morphine. In addition, hydromorphone is better absorbed orally than is morphine. In clinical settings, Hydromorphone exerts its principal pharmacological effect on the central nervous system and gastrointestinal tract. Its primary actions of therapeutic value are analgesia and sedation. Hydromorphone appears to increase the patient's tolerance for pain and to decrease discomfort, although the presence of the pain itself may still be recognized. In addition to analgesia, alterations in mood, euphoria and dysphoria, and drowsiness commonly occur. Opioids also produce respiratory depression by direct action on brain stem respiratory centers.
Hydromorphon Absorption
Better absorbed orally than morphine
Hydromorphon side effects and Toxicity
Hydromorphone is a schedule II narcotic which can lead to physical dependence or addiction. High doses lead to respiratory depression, nausea, and vomiting. Overdoses lead to extreme somnolence progressing to stupor or coma, skeletal muscle flaccidity, cold and clammy skin, and sometimes bradycardia and hypotension. In severe overdosage, apnea, circulatory collapse, cardiac arrest and death may occur.
Hydromorphon Patient Information
http://www.drugs.com/cons/Hydroflumethiazide.html
Hydromorphon Organisms Affected
Humans and other mammals
