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Clodronate Brand names, Clodronate Analogs

Clodronate Brand Names Mixture

  • No information avaliable

Clodronate Chemical_Formula


Clodronate RX_link

No information avaliable

Clodronate fda sheet

Clodronate msds (material safety sheet)

Clodronate MSDS

Clodronate Synthesis Reference

No information avaliable

Clodronate Molecular Weight

244.892 g/mol

Clodronate Melting Point

250 oC

Clodronate H2O Solubility

395 mg/L

Clodronate State


Clodronate LogP


Clodronate Dosage Forms

Capsules; Solution

Clodronate Indication

For the management of hypercalcemia of malignancy and as an adjunct in the management of osteolysis resulting from bone metastases of malignant tumors.

Clodronate Pharmacology

Clodronate is a first generation (non-nitrogenous) bisphosphonate in the same family as etidronate and tiludronate. Clodronate affects calcium metabolism and inhibits bone resorption and soft tissue calcification. Of the clodronate that is resorbed (from oral preparation) or infused (for intravenous drugs), about 50% is excreted unchanged by the kidney. The remainder has a very high affinity for bone tissue, and is rapidly absorbed onto the bone surface. Clodronate has been shown to prevent or delay skeletal-related events and decrease bone pain as well as normalize calcium levels in the presence of hypercalcemia.

Clodronate Absorption

After oral administration, absorption is estimated at 1–3% of the ingested dose because of the low uptake from the gastrointestinal tract.

Clodronate side effects and Toxicity

Decreases in serum calcium following substantial overdosage may be expected in some patients. Signs and symptoms of hypocalcemia also may occur in some of these patients.

Clodronate Patient Information

No information avaliable

Clodronate Organisms Affected

Humans and other mammals