Clodronate
Clodronate Brand names, Clodronate Analogs
Clodronate Brand Names Mixture
- No information avaliable
Clodronate Chemical_Formula
CH4Cl2O6P2
Clodronate RX_link
No information avaliable
Clodronate fda sheet
Clodronate msds (material safety sheet)
Clodronate Synthesis Reference
No information avaliable
Clodronate Molecular Weight
244.892 g/mol
Clodronate Melting Point
250 oC
Clodronate H2O Solubility
395 mg/L
Clodronate State
Solid
Clodronate LogP
-0.906
Clodronate Dosage Forms
Capsules; Solution
Clodronate Indication
For the management of hypercalcemia of malignancy and as an adjunct in the management of osteolysis resulting from bone metastases of malignant tumors.
Clodronate Pharmacology
Clodronate is a first generation (non-nitrogenous) bisphosphonate in the same family as etidronate and tiludronate. Clodronate affects calcium metabolism and inhibits bone resorption and soft tissue calcification. Of the clodronate that is resorbed (from oral preparation) or infused (for intravenous drugs), about 50% is excreted unchanged by the kidney. The remainder has a very high affinity for bone tissue, and is rapidly absorbed onto the bone surface. Clodronate has been shown to prevent or delay skeletal-related events and decrease bone pain as well as normalize calcium levels in the presence of hypercalcemia.
Clodronate Absorption
After oral administration, absorption is estimated at 1–3% of the ingested dose because of the low uptake from the gastrointestinal tract.
Clodronate side effects and Toxicity
Decreases in serum calcium following substantial overdosage may be expected in some patients. Signs and symptoms of hypocalcemia also may occur in some of these patients.
Clodronate Patient Information
No information avaliable
Clodronate Organisms Affected
Humans and other mammals
