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Acidum Clodronicum [Inn-Latin] en es it fr

Acidum Clodronicum [Inn-Latin] Brand names, Acidum Clodronicum [Inn-Latin] Analogs

Acidum Clodronicum [Inn-Latin] Brand Names Mixture

  • No information avaliable

Acidum Clodronicum [Inn-Latin] Chemical_Formula

CH4Cl2O6P2

Acidum Clodronicum [Inn-Latin] RX_link

No information avaliable

Acidum Clodronicum [Inn-Latin] fda sheet

Acidum Clodronicum [Inn-Latin] msds (material safety sheet)

Acidum_Clodronicum_[Inn-Latin] MSDS

Acidum Clodronicum [Inn-Latin] Synthesis Reference

No information avaliable

Acidum Clodronicum [Inn-Latin] Molecular Weight

244.892 g/mol

Acidum Clodronicum [Inn-Latin] Melting Point

250 oC

Acidum Clodronicum [Inn-Latin] H2O Solubility

395 mg/L

Acidum Clodronicum [Inn-Latin] State

Solid

Acidum Clodronicum [Inn-Latin] LogP

-0.906

Acidum Clodronicum [Inn-Latin] Dosage Forms

Capsules; Solution

Acidum Clodronicum [Inn-Latin] Indication

For the management of hypercalcemia of malignancy and as an adjunct in the management of osteolysis resulting from bone metastases of malignant tumors.

Acidum Clodronicum [Inn-Latin] Pharmacology

Clodronate is a first generation (non-nitrogenous) bisphosphonate in the same family as etidronate and tiludronate. Clodronate affects calcium metabolism and inhibits bone resorption and soft tissue calcification. Of the clodronate that is resorbed (from oral preparation) or infused (for intravenous drugs), about 50% is excreted unchanged by the kidney. The remainder has a very high affinity for bone tissue, and is rapidly absorbed onto the bone surface. Clodronate has been shown to prevent or delay skeletal-related events and decrease bone pain as well as normalize calcium levels in the presence of hypercalcemia.

Acidum Clodronicum [Inn-Latin] Absorption

After oral administration, absorption is estimated at 1–3% of the ingested dose because of the low uptake from the gastrointestinal tract.

Acidum Clodronicum [Inn-Latin] side effects and Toxicity

Decreases in serum calcium following substantial overdosage may be expected in some patients. Signs and symptoms of hypocalcemia also may occur in some of these patients.

Acidum Clodronicum [Inn-Latin] Patient Information

No information avaliable

Acidum Clodronicum [Inn-Latin] Organisms Affected

Humans and other mammals