Dichloromethylidene diphosphonate
Dichloromethylidene diphosphonate Brand names, Dichloromethylidene diphosphonate Analogs
Dichloromethylidene diphosphonate Brand Names Mixture
- No information avaliable
Dichloromethylidene diphosphonate Chemical_Formula
CH4Cl2O6P2
Dichloromethylidene diphosphonate RX_link
No information avaliable
Dichloromethylidene diphosphonate fda sheet
Dichloromethylidene diphosphonate msds (material safety sheet)
Dichloromethylidene diphosphonate Synthesis Reference
No information avaliable
Dichloromethylidene diphosphonate Molecular Weight
244.892 g/mol
Dichloromethylidene diphosphonate Melting Point
250 oC
Dichloromethylidene diphosphonate H2O Solubility
395 mg/L
Dichloromethylidene diphosphonate State
Solid
Dichloromethylidene diphosphonate LogP
-0.906
Dichloromethylidene diphosphonate Dosage Forms
Capsules; Solution
Dichloromethylidene diphosphonate Indication
For the management of hypercalcemia of malignancy and as an adjunct in the management of osteolysis resulting from bone metastases of malignant tumors.
Dichloromethylidene diphosphonate Pharmacology
Clodronate is a first generation (non-nitrogenous) bisphosphonate in the same family as etidronate and tiludronate. Clodronate affects calcium metabolism and inhibits bone resorption and soft tissue calcification. Of the clodronate that is resorbed (from oral preparation) or infused (for intravenous drugs), about 50% is excreted unchanged by the kidney. The remainder has a very high affinity for bone tissue, and is rapidly absorbed onto the bone surface. Clodronate has been shown to prevent or delay skeletal-related events and decrease bone pain as well as normalize calcium levels in the presence of hypercalcemia.
Dichloromethylidene diphosphonate Absorption
After oral administration, absorption is estimated at 1–3% of the ingested dose because of the low uptake from the gastrointestinal tract.
Dichloromethylidene diphosphonate side effects and Toxicity
Decreases in serum calcium following substantial overdosage may be expected in some patients. Signs and symptoms of hypocalcemia also may occur in some of these patients.
Dichloromethylidene diphosphonate Patient Information
No information avaliable
Dichloromethylidene diphosphonate Organisms Affected
Humans and other mammals
