Dichloromethylidene diphosphonate en es it fr

Dichloromethylidene diphosphonate Brand names, Dichloromethylidene diphosphonate Analogs

Dichloromethylidene diphosphonate Brand Names Mixture

  • No information avaliable

Dichloromethylidene diphosphonate Chemical_Formula

CH4Cl2O6P2

Dichloromethylidene diphosphonate RX_link

No information avaliable

Dichloromethylidene diphosphonate fda sheet

Dichloromethylidene diphosphonate msds (material safety sheet)

Dichloromethylidene_diphosphonate MSDS

Dichloromethylidene diphosphonate Synthesis Reference

No information avaliable

Dichloromethylidene diphosphonate Molecular Weight

244.892 g/mol

Dichloromethylidene diphosphonate Melting Point

250 oC

Dichloromethylidene diphosphonate H2O Solubility

395 mg/L

Dichloromethylidene diphosphonate State

Solid

Dichloromethylidene diphosphonate LogP

-0.906

Dichloromethylidene diphosphonate Dosage Forms

Capsules; Solution

Dichloromethylidene diphosphonate Indication

For the management of hypercalcemia of malignancy and as an adjunct in the management of osteolysis resulting from bone metastases of malignant tumors.

Dichloromethylidene diphosphonate Pharmacology

Clodronate is a first generation (non-nitrogenous) bisphosphonate in the same family as etidronate and tiludronate. Clodronate affects calcium metabolism and inhibits bone resorption and soft tissue calcification. Of the clodronate that is resorbed (from oral preparation) or infused (for intravenous drugs), about 50% is excreted unchanged by the kidney. The remainder has a very high affinity for bone tissue, and is rapidly absorbed onto the bone surface. Clodronate has been shown to prevent or delay skeletal-related events and decrease bone pain as well as normalize calcium levels in the presence of hypercalcemia.

Dichloromethylidene diphosphonate Absorption

After oral administration, absorption is estimated at 1–3% of the ingested dose because of the low uptake from the gastrointestinal tract.

Dichloromethylidene diphosphonate side effects and Toxicity

Decreases in serum calcium following substantial overdosage may be expected in some patients. Signs and symptoms of hypocalcemia also may occur in some of these patients.

Dichloromethylidene diphosphonate Patient Information

No information avaliable

Dichloromethylidene diphosphonate Organisms Affected

Humans and other mammals