Clasteon
Clasteon Brand names, Clasteon Analogs
Clasteon Brand Names Mixture
- No information avaliable
Clasteon Chemical_Formula
CH4Cl2O6P2
Clasteon RX_link
No information avaliable
Clasteon fda sheet
Clasteon msds (material safety sheet)
Clasteon Synthesis Reference
No information avaliable
Clasteon Molecular Weight
244.892 g/mol
Clasteon Melting Point
250 oC
Clasteon H2O Solubility
395 mg/L
Clasteon State
Solid
Clasteon LogP
-0.906
Clasteon Dosage Forms
Capsules; Solution
Clasteon Indication
For the management of hypercalcemia of malignancy and as an adjunct in the management of osteolysis resulting from bone metastases of malignant tumors.
Clasteon Pharmacology
Clodronate is a first generation (non-nitrogenous) bisphosphonate in the same family as etidronate and tiludronate. Clodronate affects calcium metabolism and inhibits bone resorption and soft tissue calcification. Of the clodronate that is resorbed (from oral preparation) or infused (for intravenous drugs), about 50% is excreted unchanged by the kidney. The remainder has a very high affinity for bone tissue, and is rapidly absorbed onto the bone surface. Clodronate has been shown to prevent or delay skeletal-related events and decrease bone pain as well as normalize calcium levels in the presence of hypercalcemia.
Clasteon Absorption
After oral administration, absorption is estimated at 1–3% of the ingested dose because of the low uptake from the gastrointestinal tract.
Clasteon side effects and Toxicity
Decreases in serum calcium following substantial overdosage may be expected in some patients. Signs and symptoms of hypocalcemia also may occur in some of these patients.
Clasteon Patient Information
No information avaliable
Clasteon Organisms Affected
Humans and other mammals
