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Acide Clodronique [Inn-French] en es it fr

Acide Clodronique [Inn-French] Brand names, Acide Clodronique [Inn-French] Analogs

Acide Clodronique [Inn-French] Brand Names Mixture

  • No information avaliable

Acide Clodronique [Inn-French] Chemical_Formula

CH4Cl2O6P2

Acide Clodronique [Inn-French] RX_link

No information avaliable

Acide Clodronique [Inn-French] fda sheet

Acide Clodronique [Inn-French] msds (material safety sheet)

Acide_Clodronique_[Inn-French] MSDS

Acide Clodronique [Inn-French] Synthesis Reference

No information avaliable

Acide Clodronique [Inn-French] Molecular Weight

244.892 g/mol

Acide Clodronique [Inn-French] Melting Point

250 oC

Acide Clodronique [Inn-French] H2O Solubility

395 mg/L

Acide Clodronique [Inn-French] State

Solid

Acide Clodronique [Inn-French] LogP

-0.906

Acide Clodronique [Inn-French] Dosage Forms

Capsules; Solution

Acide Clodronique [Inn-French] Indication

For the management of hypercalcemia of malignancy and as an adjunct in the management of osteolysis resulting from bone metastases of malignant tumors.

Acide Clodronique [Inn-French] Pharmacology

Clodronate is a first generation (non-nitrogenous) bisphosphonate in the same family as etidronate and tiludronate. Clodronate affects calcium metabolism and inhibits bone resorption and soft tissue calcification. Of the clodronate that is resorbed (from oral preparation) or infused (for intravenous drugs), about 50% is excreted unchanged by the kidney. The remainder has a very high affinity for bone tissue, and is rapidly absorbed onto the bone surface. Clodronate has been shown to prevent or delay skeletal-related events and decrease bone pain as well as normalize calcium levels in the presence of hypercalcemia.

Acide Clodronique [Inn-French] Absorption

After oral administration, absorption is estimated at 1–3% of the ingested dose because of the low uptake from the gastrointestinal tract.

Acide Clodronique [Inn-French] side effects and Toxicity

Decreases in serum calcium following substantial overdosage may be expected in some patients. Signs and symptoms of hypocalcemia also may occur in some of these patients.

Acide Clodronique [Inn-French] Patient Information

No information avaliable

Acide Clodronique [Inn-French] Organisms Affected

Humans and other mammals