Bonefos
Bonefos Brand names, Bonefos Analogs
Bonefos Brand Names Mixture
- No information avaliable
Bonefos Chemical_Formula
CH4Cl2O6P2
Bonefos RX_link
No information avaliable
Bonefos fda sheet
Bonefos msds (material safety sheet)
Bonefos Synthesis Reference
No information avaliable
Bonefos Molecular Weight
244.892 g/mol
Bonefos Melting Point
250 oC
Bonefos H2O Solubility
395 mg/L
Bonefos State
Solid
Bonefos LogP
-0.906
Bonefos Dosage Forms
Capsules; Solution
Bonefos Indication
For the management of hypercalcemia of malignancy and as an adjunct in the management of osteolysis resulting from bone metastases of malignant tumors.
Bonefos Pharmacology
Clodronate is a first generation (non-nitrogenous) bisphosphonate in the same family as etidronate and tiludronate. Clodronate affects calcium metabolism and inhibits bone resorption and soft tissue calcification. Of the clodronate that is resorbed (from oral preparation) or infused (for intravenous drugs), about 50% is excreted unchanged by the kidney. The remainder has a very high affinity for bone tissue, and is rapidly absorbed onto the bone surface. Clodronate has been shown to prevent or delay skeletal-related events and decrease bone pain as well as normalize calcium levels in the presence of hypercalcemia.
Bonefos Absorption
After oral administration, absorption is estimated at 1–3% of the ingested dose because of the low uptake from the gastrointestinal tract.
Bonefos side effects and Toxicity
Decreases in serum calcium following substantial overdosage may be expected in some patients. Signs and symptoms of hypocalcemia also may occur in some of these patients.
Bonefos Patient Information
No information avaliable
Bonefos Organisms Affected
Humans and other mammals
