Dichloromethanediphosphonic acid
Dichloromethanediphosphonic acid Brand names, Dichloromethanediphosphonic acid Analogs
Dichloromethanediphosphonic acid Brand Names Mixture
- No information avaliable
Dichloromethanediphosphonic acid Chemical_Formula
CH4Cl2O6P2
Dichloromethanediphosphonic acid RX_link
No information avaliable
Dichloromethanediphosphonic acid fda sheet
Dichloromethanediphosphonic acid msds (material safety sheet)
Dichloromethanediphosphonic acid Synthesis Reference
No information avaliable
Dichloromethanediphosphonic acid Molecular Weight
244.892 g/mol
Dichloromethanediphosphonic acid Melting Point
250 oC
Dichloromethanediphosphonic acid H2O Solubility
395 mg/L
Dichloromethanediphosphonic acid State
Solid
Dichloromethanediphosphonic acid LogP
-0.906
Dichloromethanediphosphonic acid Dosage Forms
Capsules; Solution
Dichloromethanediphosphonic acid Indication
For the management of hypercalcemia of malignancy and as an adjunct in the management of osteolysis resulting from bone metastases of malignant tumors.
Dichloromethanediphosphonic acid Pharmacology
Clodronate is a first generation (non-nitrogenous) bisphosphonate in the same family as etidronate and tiludronate. Clodronate affects calcium metabolism and inhibits bone resorption and soft tissue calcification. Of the clodronate that is resorbed (from oral preparation) or infused (for intravenous drugs), about 50% is excreted unchanged by the kidney. The remainder has a very high affinity for bone tissue, and is rapidly absorbed onto the bone surface. Clodronate has been shown to prevent or delay skeletal-related events and decrease bone pain as well as normalize calcium levels in the presence of hypercalcemia.
Dichloromethanediphosphonic acid Absorption
After oral administration, absorption is estimated at 1–3% of the ingested dose because of the low uptake from the gastrointestinal tract.
Dichloromethanediphosphonic acid side effects and Toxicity
Decreases in serum calcium following substantial overdosage may be expected in some patients. Signs and symptoms of hypocalcemia also may occur in some of these patients.
Dichloromethanediphosphonic acid Patient Information
No information avaliable
Dichloromethanediphosphonic acid Organisms Affected
Humans and other mammals
