PharmacyCodes



Acido Clodronico [Inn-Spanish] en es it fr

Acido Clodronico [Inn-Spanish] Brand names, Acido Clodronico [Inn-Spanish] Analogs

Acido Clodronico [Inn-Spanish] Brand Names Mixture

  • No information avaliable

Acido Clodronico [Inn-Spanish] Chemical_Formula

CH4Cl2O6P2

Acido Clodronico [Inn-Spanish] RX_link

No information avaliable

Acido Clodronico [Inn-Spanish] fda sheet

Acido Clodronico [Inn-Spanish] msds (material safety sheet)

Acido_Clodronico_[Inn-Spanish] MSDS

Acido Clodronico [Inn-Spanish] Synthesis Reference

No information avaliable

Acido Clodronico [Inn-Spanish] Molecular Weight

244.892 g/mol

Acido Clodronico [Inn-Spanish] Melting Point

250 oC

Acido Clodronico [Inn-Spanish] H2O Solubility

395 mg/L

Acido Clodronico [Inn-Spanish] State

Solid

Acido Clodronico [Inn-Spanish] LogP

-0.906

Acido Clodronico [Inn-Spanish] Dosage Forms

Capsules; Solution

Acido Clodronico [Inn-Spanish] Indication

For the management of hypercalcemia of malignancy and as an adjunct in the management of osteolysis resulting from bone metastases of malignant tumors.

Acido Clodronico [Inn-Spanish] Pharmacology

Clodronate is a first generation (non-nitrogenous) bisphosphonate in the same family as etidronate and tiludronate. Clodronate affects calcium metabolism and inhibits bone resorption and soft tissue calcification. Of the clodronate that is resorbed (from oral preparation) or infused (for intravenous drugs), about 50% is excreted unchanged by the kidney. The remainder has a very high affinity for bone tissue, and is rapidly absorbed onto the bone surface. Clodronate has been shown to prevent or delay skeletal-related events and decrease bone pain as well as normalize calcium levels in the presence of hypercalcemia.

Acido Clodronico [Inn-Spanish] Absorption

After oral administration, absorption is estimated at 1–3% of the ingested dose because of the low uptake from the gastrointestinal tract.

Acido Clodronico [Inn-Spanish] side effects and Toxicity

Decreases in serum calcium following substantial overdosage may be expected in some patients. Signs and symptoms of hypocalcemia also may occur in some of these patients.

Acido Clodronico [Inn-Spanish] Patient Information

No information avaliable

Acido Clodronico [Inn-Spanish] Organisms Affected

Humans and other mammals