Amikacin
Amikacin Brand names, Amikacin Analogs
Amikacin Brand Names Mixture
- No information avaliable
Amikacin Chemical_Formula
C22H43N5O13
Amikacin RX_link
http://www.rxlist.com/cgi/generic3/amikacin.htm
Amikacin fda sheet
Amikacin msds (material safety sheet)
Amikacin Synthesis Reference
H. Kawaguchi, T. Naito, Ger. pat. 2,234,315; H. Kawaguchi et al., U.S. pat. 3,781,268 (both 1973 to Bristol-Myers)
Amikacin Molecular Weight
585.603 g/mol
Amikacin Melting Point
203-204 oC
Amikacin H2O Solubility
1.85E+005 mg/L
Amikacin State
Solid
Amikacin LogP
-9.048
Amikacin Dosage Forms
IM infusion; IM injection
Amikacin Indication
For short-term treatment of serious infections due to susceptible strains of Gram-negative bacteria, including Pseudomonas species, Escherichia coli, species of indole-positive and indole-negative Proteus, Providencia species, Klebsiella-Enterobacter-Serratia species, and Acinetobacter (Mima-Herellea) species.
Amikacin Pharmacology
Amikacin is an aminoglycoside antibiotic. Aminoglycosides work by binding to the bacterial 30S ribosomal subunit, causing misreading of t-RNA, leaving the bacterium unable to synthesize proteins vital to its growth. Aminoglycosides are useful primarily in infections involving aerobic, Gram-negative bacteria, such as Pseudomonas, Acinetobacter, and Enterobacter. In addition, some mycobacteria, including the bacteria that cause tuberculosis, are susceptible to aminoglycosides. Infections caused by Gram-positive bacteria can also be treated with aminoglycosides, but other types of antibiotics are more potent and less damaging to the host. In the past the aminoglycosides have been used in conjunction with penicillin-related antibiotics in streptococcal infections for their synergistic effects, particularly in endocarditis. Aminoglycosides are mostly ineffective against anaerobic bacteria, fungi and viruses.
Amikacin Absorption
Rapidly absorbed after intramuscular administration
Amikacin side effects and Toxicity
No information avaliable
Amikacin Patient Information
Amikacin Organisms Affected
Enteric bacteria and other eubacteria
