Amikacin Dihydrate
Amikacin Dihydrate Brand names, Amikacin Dihydrate Analogs
Amikacin Dihydrate Brand Names Mixture
- No information avaliable
Amikacin Dihydrate Chemical_Formula
C22H43N5O13
Amikacin Dihydrate RX_link
http://www.rxlist.com/cgi/generic3/amikacin.htm
Amikacin Dihydrate fda sheet
Amikacin Dihydrate msds (material safety sheet)
Amikacin Dihydrate Synthesis Reference
H. Kawaguchi, T. Naito, Ger. pat. 2,234,315; H. Kawaguchi et al., U.S. pat. 3,781,268 (both 1973 to Bristol-Myers)
Amikacin Dihydrate Molecular Weight
585.603 g/mol
Amikacin Dihydrate Melting Point
203-204 oC
Amikacin Dihydrate H2O Solubility
1.85E+005 mg/L
Amikacin Dihydrate State
Solid
Amikacin Dihydrate LogP
-9.048
Amikacin Dihydrate Dosage Forms
IM infusion; IM injection
Amikacin Dihydrate Indication
For short-term treatment of serious infections due to susceptible strains of Gram-negative bacteria, including Pseudomonas species, Escherichia coli, species of indole-positive and indole-negative Proteus, Providencia species, Klebsiella-Enterobacter-Serratia species, and Acinetobacter (Mima-Herellea) species.
Amikacin Dihydrate Pharmacology
Amikacin is an aminoglycoside antibiotic. Aminoglycosides work by binding to the bacterial 30S ribosomal subunit, causing misreading of t-RNA, leaving the bacterium unable to synthesize proteins vital to its growth. Aminoglycosides are useful primarily in infections involving aerobic, Gram-negative bacteria, such as Pseudomonas, Acinetobacter, and Enterobacter. In addition, some mycobacteria, including the bacteria that cause tuberculosis, are susceptible to aminoglycosides. Infections caused by Gram-positive bacteria can also be treated with aminoglycosides, but other types of antibiotics are more potent and less damaging to the host. In the past the aminoglycosides have been used in conjunction with penicillin-related antibiotics in streptococcal infections for their synergistic effects, particularly in endocarditis. Aminoglycosides are mostly ineffective against anaerobic bacteria, fungi and viruses.
Amikacin Dihydrate Absorption
Rapidly absorbed after intramuscular administration
Amikacin Dihydrate side effects and Toxicity
No information avaliable
Amikacin Dihydrate Patient Information
Amikacin Dihydrate Organisms Affected
Enteric bacteria and other eubacteria
