Amicacin
Amicacin Brand names, Amicacin Analogs
Amicacin Brand Names Mixture
- No information avaliable
Amicacin Chemical_Formula
C22H43N5O13
Amicacin RX_link
http://www.rxlist.com/cgi/generic3/amikacin.htm
Amicacin fda sheet
Amicacin msds (material safety sheet)
Amicacin Synthesis Reference
H. Kawaguchi, T. Naito, Ger. pat. 2,234,315; H. Kawaguchi et al., U.S. pat. 3,781,268 (both 1973 to Bristol-Myers)
Amicacin Molecular Weight
585.603 g/mol
Amicacin Melting Point
203-204 oC
Amicacin H2O Solubility
1.85E+005 mg/L
Amicacin State
Solid
Amicacin LogP
-9.048
Amicacin Dosage Forms
IM infusion; IM injection
Amicacin Indication
For short-term treatment of serious infections due to susceptible strains of Gram-negative bacteria, including Pseudomonas species, Escherichia coli, species of indole-positive and indole-negative Proteus, Providencia species, Klebsiella-Enterobacter-Serratia species, and Acinetobacter (Mima-Herellea) species.
Amicacin Pharmacology
Amikacin is an aminoglycoside antibiotic. Aminoglycosides work by binding to the bacterial 30S ribosomal subunit, causing misreading of t-RNA, leaving the bacterium unable to synthesize proteins vital to its growth. Aminoglycosides are useful primarily in infections involving aerobic, Gram-negative bacteria, such as Pseudomonas, Acinetobacter, and Enterobacter. In addition, some mycobacteria, including the bacteria that cause tuberculosis, are susceptible to aminoglycosides. Infections caused by Gram-positive bacteria can also be treated with aminoglycosides, but other types of antibiotics are more potent and less damaging to the host. In the past the aminoglycosides have been used in conjunction with penicillin-related antibiotics in streptococcal infections for their synergistic effects, particularly in endocarditis. Aminoglycosides are mostly ineffective against anaerobic bacteria, fungi and viruses.
Amicacin Absorption
Rapidly absorbed after intramuscular administration
Amicacin side effects and Toxicity
No information avaliable
Amicacin Patient Information
Amicacin Organisms Affected
Enteric bacteria and other eubacteria
