Briclin
Briclin Brand names, Briclin Analogs
Briclin Brand Names Mixture
- No information avaliable
Briclin Chemical_Formula
C22H43N5O13
Briclin RX_link
http://www.rxlist.com/cgi/generic3/amikacin.htm
Briclin fda sheet
Briclin msds (material safety sheet)
Briclin Synthesis Reference
H. Kawaguchi, T. Naito, Ger. pat. 2,234,315; H. Kawaguchi et al., U.S. pat. 3,781,268 (both 1973 to Bristol-Myers)
Briclin Molecular Weight
585.603 g/mol
Briclin Melting Point
203-204 oC
Briclin H2O Solubility
1.85E+005 mg/L
Briclin State
Solid
Briclin LogP
-9.048
Briclin Dosage Forms
IM infusion; IM injection
Briclin Indication
For short-term treatment of serious infections due to susceptible strains of Gram-negative bacteria, including Pseudomonas species, Escherichia coli, species of indole-positive and indole-negative Proteus, Providencia species, Klebsiella-Enterobacter-Serratia species, and Acinetobacter (Mima-Herellea) species.
Briclin Pharmacology
Amikacin is an aminoglycoside antibiotic. Aminoglycosides work by binding to the bacterial 30S ribosomal subunit, causing misreading of t-RNA, leaving the bacterium unable to synthesize proteins vital to its growth. Aminoglycosides are useful primarily in infections involving aerobic, Gram-negative bacteria, such as Pseudomonas, Acinetobacter, and Enterobacter. In addition, some mycobacteria, including the bacteria that cause tuberculosis, are susceptible to aminoglycosides. Infections caused by Gram-positive bacteria can also be treated with aminoglycosides, but other types of antibiotics are more potent and less damaging to the host. In the past the aminoglycosides have been used in conjunction with penicillin-related antibiotics in streptococcal infections for their synergistic effects, particularly in endocarditis. Aminoglycosides are mostly ineffective against anaerobic bacteria, fungi and viruses.
Briclin Absorption
Rapidly absorbed after intramuscular administration
Briclin side effects and Toxicity
No information avaliable
Briclin Patient Information
Briclin Organisms Affected
Enteric bacteria and other eubacteria
