Amikacinum [Inn-Latin]

Amikacinum [Inn-Latin] Brand names, Amikacinum [Inn-Latin] Analogs

Amikacinum [Inn-Latin] Brand Names Mixture

No information avaliable

Amikacinum [Inn-Latin] Chemical_Formula

C₂₂H₄₃N₅O₁₃

Amikacinum [Inn-Latin] RX_link

http://www.rxlist.com/cgi/generic3/amikacin.htm

Amikacinum [Inn-Latin] fda sheet

Amikacinum [Inn-Latin] msds (material safety sheet)

Amikacinum_[Inn-Latin] MSDS

Amikacinum [Inn-Latin] Synthesis Reference

H. Kawaguchi, T. Naito, Ger. pat. 2,234,315; H. Kawaguchi et al., U.S. pat. 3,781,268 (both 1973 to Bristol-Myers)

Amikacinum [Inn-Latin] Molecular Weight

585.603 g/mol

Amikacinum [Inn-Latin] Melting Point

203-204 ^oC

Amikacinum [Inn-Latin] H₂O Solubility

1.85E+005 mg/L

Amikacinum [Inn-Latin] State

Solid

Amikacinum [Inn-Latin] LogP

-9.048

Amikacinum [Inn-Latin] Dosage Forms

IM infusion; IM injection

Amikacinum [Inn-Latin] Indication

For short-term treatment of serious infections due to susceptible strains of Gram-negative bacteria, including Pseudomonas species, Escherichia coli, species of indole-positive and indole-negative Proteus, Providencia species, Klebsiella-Enterobacter-Serratia species, and Acinetobacter (Mima-Herellea) species.

Amikacinum [Inn-Latin] Pharmacology

Amikacin is an aminoglycoside antibiotic. Aminoglycosides work by binding to the bacterial 30S ribosomal subunit, causing misreading of t-RNA, leaving the bacterium unable to synthesize proteins vital to its growth. Aminoglycosides are useful primarily in infections involving aerobic, Gram-negative bacteria, such as Pseudomonas, Acinetobacter, and Enterobacter. In addition, some mycobacteria, including the bacteria that cause tuberculosis, are susceptible to aminoglycosides. Infections caused by Gram-positive bacteria can also be treated with aminoglycosides, but other types of antibiotics are more potent and less damaging to the host. In the past the aminoglycosides have been used in conjunction with penicillin-related antibiotics in streptococcal infections for their synergistic effects, particularly in endocarditis. Aminoglycosides are mostly ineffective against anaerobic bacteria, fungi and viruses.

Amikacinum [Inn-Latin] Absorption

Rapidly absorbed after intramuscular administration

Amikacinum [Inn-Latin] side effects and Toxicity

No information avaliable

Amikacinum [Inn-Latin] Patient Information

Amikacinum [Inn-Latin] Organisms Affected

Enteric bacteria and other eubacteria