Amikacin Base
Amikacin Base Brand names, Amikacin Base Analogs
Amikacin Base Brand Names Mixture
- No information avaliable
Amikacin Base Chemical_Formula
C22H43N5O13
Amikacin Base RX_link
http://www.rxlist.com/cgi/generic3/amikacin.htm
Amikacin Base fda sheet
Amikacin Base msds (material safety sheet)
Amikacin Base Synthesis Reference
H. Kawaguchi, T. Naito, Ger. pat. 2,234,315; H. Kawaguchi et al., U.S. pat. 3,781,268 (both 1973 to Bristol-Myers)
Amikacin Base Molecular Weight
585.603 g/mol
Amikacin Base Melting Point
203-204 oC
Amikacin Base H2O Solubility
1.85E+005 mg/L
Amikacin Base State
Solid
Amikacin Base LogP
-9.048
Amikacin Base Dosage Forms
IM infusion; IM injection
Amikacin Base Indication
For short-term treatment of serious infections due to susceptible strains of Gram-negative bacteria, including Pseudomonas species, Escherichia coli, species of indole-positive and indole-negative Proteus, Providencia species, Klebsiella-Enterobacter-Serratia species, and Acinetobacter (Mima-Herellea) species.
Amikacin Base Pharmacology
Amikacin is an aminoglycoside antibiotic. Aminoglycosides work by binding to the bacterial 30S ribosomal subunit, causing misreading of t-RNA, leaving the bacterium unable to synthesize proteins vital to its growth. Aminoglycosides are useful primarily in infections involving aerobic, Gram-negative bacteria, such as Pseudomonas, Acinetobacter, and Enterobacter. In addition, some mycobacteria, including the bacteria that cause tuberculosis, are susceptible to aminoglycosides. Infections caused by Gram-positive bacteria can also be treated with aminoglycosides, but other types of antibiotics are more potent and less damaging to the host. In the past the aminoglycosides have been used in conjunction with penicillin-related antibiotics in streptococcal infections for their synergistic effects, particularly in endocarditis. Aminoglycosides are mostly ineffective against anaerobic bacteria, fungi and viruses.
Amikacin Base Absorption
Rapidly absorbed after intramuscular administration
Amikacin Base side effects and Toxicity
No information avaliable
Amikacin Base Patient Information
Amikacin Base Organisms Affected
Enteric bacteria and other eubacteria
