Adran
Brand names,
Adran
Analogs
Adran
Brand Names Mixture
- Dimetapp Cold and Sinus Caplets (Ibuprofen + Pseudoephedrine Hydrochloride)
- Dristan Sinus Caplets (Ibuprofen + Pseudoephedrine Hydrochloride)
Adran
Chemical_Formula
C13H18O2
Adran
RX_link
http://www.rxlist.com/cgi/generic/ibup.htm
Adran
fda sheet
Adran
msds (material safety sheet)
Adran
Synthesis Reference
Nicholson, Adams; U.S. Pat. 3,228,831 (1966)
Adran
Molecular Weight
206.281 g/mol
Adran
Melting Point
75 - 77 oC
Adran
H2O Solubility
0.049 mg/ml
Adran
State
Solid
Adran
LogP
3.481
Adran
Dosage Forms
Tablet; Suspension
Adran
Indication
For the treatment of pain (muscular and rheumatic), sprains, strains, backache and neuralgia
Adran
Pharmacology
Ibuprofen is a nonsteroidal antiinflammatory drug (NSAID) with analgesic and antipyretic properties. Ibuprofen has pharmacologic actions similar to those of other prototypical NSAIAs, that is thought to be associated with the inhibition of prostaglandin synthesis. Ibuprofen is used to treat rheumatoid arthritis, osteoarthritis, dysmenorrhea, and to alleviate moderate pain.
Adran
Absorption
rapidly absorbed
Adran
side effects and Toxicity
Abdominal pain, breathing difficulties, coma, drowsiness, headache, irregular heartbeat, kidney failure, low blood pressure, nausea, ringing in the ears, seizures, sluggishness, vomiting; LD50=1255mg/kg(orally in mice)
Adran
Patient Information
Ibuprofen is a nonsteroidal anti-inflammatory drug (NSAID) used to relieve pain and inflammation, reduce fever,
and treat osteoarthritis, rheumatoid arthritis, and menstrual cramps. Inform your physician if you are pregnant or
nursing. Ibuprofen should not be taken during the last three months of pregnancy. Inform your physician if you use
alcohol chronically. Ibuprofen should not be taken with aspirin products. This medication should be taken with food,
milk or antacids if stomach upset occurs. Ibuprofen may cause dizziness and drowsiness; use caution while driving or
operating hazardous machinery. Ibuprofen may cause increased sensitivity to sunlight. Use sunscreens and wear
protective clothing until degree of sensitivity is determined. Notify your physician if you develop stomach pain,
bloody vomit, bloody or black tarry stools, cloudy urine, trouble breathing, rash or hives.
Adran
Organisms Affected
Humans and other mammals