Apsifen
Brand names,
Apsifen
Analogs
Apsifen
Brand Names Mixture
- Dimetapp Cold and Sinus Caplets (Ibuprofen + Pseudoephedrine Hydrochloride)
- Dristan Sinus Caplets (Ibuprofen + Pseudoephedrine Hydrochloride)
Apsifen
Chemical_Formula
C13H18O2
Apsifen
RX_link
http://www.rxlist.com/cgi/generic/ibup.htm
Apsifen
fda sheet
Apsifen
msds (material safety sheet)
Apsifen
Synthesis Reference
Nicholson, Adams; U.S. Pat. 3,228,831 (1966)
Apsifen
Molecular Weight
206.281 g/mol
Apsifen
Melting Point
75 - 77 oC
Apsifen
H2O Solubility
0.049 mg/ml
Apsifen
State
Solid
Apsifen
LogP
3.481
Apsifen
Dosage Forms
Tablet; Suspension
Apsifen
Indication
For the treatment of pain (muscular and rheumatic), sprains, strains, backache and neuralgia
Apsifen
Pharmacology
Ibuprofen is a nonsteroidal antiinflammatory drug (NSAID) with analgesic and antipyretic properties. Ibuprofen has pharmacologic actions similar to those of other prototypical NSAIAs, that is thought to be associated with the inhibition of prostaglandin synthesis. Ibuprofen is used to treat rheumatoid arthritis, osteoarthritis, dysmenorrhea, and to alleviate moderate pain.
Apsifen
Absorption
rapidly absorbed
Apsifen
side effects and Toxicity
Abdominal pain, breathing difficulties, coma, drowsiness, headache, irregular heartbeat, kidney failure, low blood pressure, nausea, ringing in the ears, seizures, sluggishness, vomiting; LD50=1255mg/kg(orally in mice)
Apsifen
Patient Information
Ibuprofen is a nonsteroidal anti-inflammatory drug (NSAID) used to relieve pain and inflammation, reduce fever,
and treat osteoarthritis, rheumatoid arthritis, and menstrual cramps. Inform your physician if you are pregnant or
nursing. Ibuprofen should not be taken during the last three months of pregnancy. Inform your physician if you use
alcohol chronically. Ibuprofen should not be taken with aspirin products. This medication should be taken with food,
milk or antacids if stomach upset occurs. Ibuprofen may cause dizziness and drowsiness; use caution while driving or
operating hazardous machinery. Ibuprofen may cause increased sensitivity to sunlight. Use sunscreens and wear
protective clothing until degree of sensitivity is determined. Notify your physician if you develop stomach pain,
bloody vomit, bloody or black tarry stools, cloudy urine, trouble breathing, rash or hives.
Apsifen
Organisms Affected
Humans and other mammals