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Brand names,
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Analogs
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Brand Names Mixture
- Dimetapp Cold and Sinus Caplets (Ibuprofen + Pseudoephedrine Hydrochloride)
- Dristan Sinus Caplets (Ibuprofen + Pseudoephedrine Hydrochloride)
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Chemical_Formula
C13H18O2
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RX_link
http://www.rxlist.com/cgi/generic/ibup.htm
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fda sheet
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msds (material safety sheet)
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Synthesis Reference
Nicholson, Adams; U.S. Pat. 3,228,831 (1966)
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Molecular Weight
206.281 g/mol
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Melting Point
75 - 77 oC
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H2O Solubility
0.049 mg/ml
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State
Solid
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LogP
3.481
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Dosage Forms
Tablet; Suspension
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Indication
For the treatment of pain (muscular and rheumatic), sprains, strains, backache and neuralgia
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Pharmacology
Ibuprofen is a nonsteroidal antiinflammatory drug (NSAID) with analgesic and antipyretic properties. Ibuprofen has pharmacologic actions similar to those of other prototypical NSAIAs, that is thought to be associated with the inhibition of prostaglandin synthesis. Ibuprofen is used to treat rheumatoid arthritis, osteoarthritis, dysmenorrhea, and to alleviate moderate pain.
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Absorption
rapidly absorbed
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side effects and Toxicity
Abdominal pain, breathing difficulties, coma, drowsiness, headache, irregular heartbeat, kidney failure, low blood pressure, nausea, ringing in the ears, seizures, sluggishness, vomiting; LD50=1255mg/kg(orally in mice)
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Patient Information
Ibuprofen is a nonsteroidal anti-inflammatory drug (NSAID) used to relieve pain and inflammation, reduce fever,
and treat osteoarthritis, rheumatoid arthritis, and menstrual cramps. Inform your physician if you are pregnant or
nursing. Ibuprofen should not be taken during the last three months of pregnancy. Inform your physician if you use
alcohol chronically. Ibuprofen should not be taken with aspirin products. This medication should be taken with food,
milk or antacids if stomach upset occurs. Ibuprofen may cause dizziness and drowsiness; use caution while driving or
operating hazardous machinery. Ibuprofen may cause increased sensitivity to sunlight. Use sunscreens and wear
protective clothing until degree of sensitivity is determined. Notify your physician if you develop stomach pain,
bloody vomit, bloody or black tarry stools, cloudy urine, trouble breathing, rash or hives.
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Organisms Affected
Humans and other mammals