Rufen
Brand names,
Rufen
Analogs
Rufen
Brand Names Mixture
- Dimetapp Cold and Sinus Caplets (Ibuprofen + Pseudoephedrine Hydrochloride)
- Dristan Sinus Caplets (Ibuprofen + Pseudoephedrine Hydrochloride)
Rufen
Chemical_Formula
C13H18O2
Rufen
RX_link
http://www.rxlist.com/cgi/generic/ibup.htm
Rufen
fda sheet
Rufen
msds (material safety sheet)
Rufen
Synthesis Reference
Nicholson, Adams; U.S. Pat. 3,228,831 (1966)
Rufen
Molecular Weight
206.281 g/mol
Rufen
Melting Point
75 - 77 oC
Rufen
H2O Solubility
0.049 mg/ml
Rufen
State
Solid
Rufen
LogP
3.481
Rufen
Dosage Forms
Tablet; Suspension
Rufen
Indication
For the treatment of pain (muscular and rheumatic), sprains, strains, backache and neuralgia
Rufen
Pharmacology
Ibuprofen is a nonsteroidal antiinflammatory drug (NSAID) with analgesic and antipyretic properties. Ibuprofen has pharmacologic actions similar to those of other prototypical NSAIAs, that is thought to be associated with the inhibition of prostaglandin synthesis. Ibuprofen is used to treat rheumatoid arthritis, osteoarthritis, dysmenorrhea, and to alleviate moderate pain.
Rufen
Absorption
rapidly absorbed
Rufen
side effects and Toxicity
Abdominal pain, breathing difficulties, coma, drowsiness, headache, irregular heartbeat, kidney failure, low blood pressure, nausea, ringing in the ears, seizures, sluggishness, vomiting; LD50=1255mg/kg(orally in mice)
Rufen
Patient Information
Ibuprofen is a nonsteroidal anti-inflammatory drug (NSAID) used to relieve pain and inflammation, reduce fever,
and treat osteoarthritis, rheumatoid arthritis, and menstrual cramps. Inform your physician if you are pregnant or
nursing. Ibuprofen should not be taken during the last three months of pregnancy. Inform your physician if you use
alcohol chronically. Ibuprofen should not be taken with aspirin products. This medication should be taken with food,
milk or antacids if stomach upset occurs. Ibuprofen may cause dizziness and drowsiness; use caution while driving or
operating hazardous machinery. Ibuprofen may cause increased sensitivity to sunlight. Use sunscreens and wear
protective clothing until degree of sensitivity is determined. Notify your physician if you develop stomach pain,
bloody vomit, bloody or black tarry stools, cloudy urine, trouble breathing, rash or hives.
Rufen
Organisms Affected
Humans and other mammals