PharmacyCodes



Phenylindione en es it fr

Phenylindione Brand names, Phenylindione Analogs

Phenylindione Brand Names Mixture

  • No information avaliable

Phenylindione Chemical_Formula

C15H10O2

Phenylindione RX_link

No information avaliable

Phenylindione fda sheet

Phenylindione msds (material safety sheet)

Phenylindione MSDS

Phenylindione Synthesis Reference

No information avaliable

Phenylindione Molecular Weight

222.239 g/mol

Phenylindione Melting Point

148-151 oC

Phenylindione H2O Solubility

27 mg/L (at 20 oC)

Phenylindione State

Solid

Phenylindione LogP

2.917

Phenylindione Dosage Forms

Tablet

Phenylindione Indication

For the treatment of pulmonary embolism, cardiomyopathy, atrial fibrillation and flutter, cerebral embolism, mural thrombosis, and thrombophili. Also used for anticoagulant prophylaxis.

Phenylindione Pharmacology

Phenindione thins the blood by antagonizing vitamin K which is required for the production of clotting factors in the liver. Anticoagulants such as Phenindione have no direct effect on an established thrombus, nor do they reverse ischemic tissue damage (damage caused by an inadequate blood supply to an organ or part of the body). However, once a thrombus has occurred, the goal of anticoagulant treatment is to prevent further extension of the formed clot and prevent secondary thromboembolic complications which may result in serious and possibly fatal sequelae. Phenindione has actions similar to warfarin, but it is now rarely employed because of its higer incidence of severe adverse effects.

Phenylindione Absorption

Absorbed slowly from the gastrointestinal tract.

Phenylindione side effects and Toxicity

Oral, mouse: LD50 = 175 mg/kg; Oral, rat: LD50 = 163 mg/kg.

Phenylindione Patient Information

No information avaliable

Phenylindione Organisms Affected

Humans and other mammals