PID
PID Brand names, PID Analogs
- Athrombon
- Bindan
- Cronodione
- Danedion
- Danilon
- Danilone
- Diadilan
- Dindevan
- Dineval
- Diophindane
- Emandion
- Emandione
- Eridione
- Fenhydren
- Fenilin
- Fenindion
- Hedulin
- Hemolidione
- Indema
- Indion
- Indon
- PID
- Phenhydren
- Phenillin
- Phenylen
- Phenylin
- Phenylindanedione
- Phenylindione
- Phenyline
- Phenyllin
- Pindione
- Rectadione
- Theradione
- Thrombasal
- Tromazal
- Trombol
PID Brand Names Mixture
- No information avaliable
PID Chemical_Formula
C15H10O2
PID RX_link
No information avaliable
PID fda sheet
PID msds (material safety sheet)
PID Synthesis Reference
No information avaliable
PID Molecular Weight
222.239 g/mol
PID Melting Point
148-151 oC
PID H2O Solubility
27 mg/L (at 20 oC)
PID State
Solid
PID LogP
2.917
PID Dosage Forms
Tablet
PID Indication
For the treatment of pulmonary embolism, cardiomyopathy, atrial fibrillation and flutter, cerebral embolism, mural thrombosis, and thrombophili. Also used for anticoagulant prophylaxis.
PID Pharmacology
Phenindione thins the blood by antagonizing vitamin K which is required for the production of clotting factors in the liver. Anticoagulants such as Phenindione have no direct effect on an established thrombus, nor do they reverse ischemic tissue damage (damage caused by an inadequate blood supply to an organ or part of the body). However, once a thrombus has occurred, the goal of anticoagulant treatment is to prevent further extension of the formed clot and prevent secondary thromboembolic complications which may result in serious and possibly fatal sequelae. Phenindione has actions similar to warfarin, but it is now rarely employed because of its higer incidence of severe adverse effects.
PID Absorption
Absorbed slowly from the gastrointestinal tract.
PID side effects and Toxicity
Oral, mouse: LD50 = 175 mg/kg; Oral, rat: LD50 = 163 mg/kg.
PID Patient Information
No information avaliable
PID Organisms Affected
Humans and other mammals
