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Thrombasal Brand names, Thrombasal Analogs

Thrombasal Brand Names Mixture

  • No information avaliable

Thrombasal Chemical_Formula

C15H10O2

Thrombasal RX_link

No information avaliable

Thrombasal fda sheet

Thrombasal msds (material safety sheet)

Thrombasal MSDS

Thrombasal Synthesis Reference

No information avaliable

Thrombasal Molecular Weight

222.239 g/mol

Thrombasal Melting Point

148-151 oC

Thrombasal H2O Solubility

27 mg/L (at 20 oC)

Thrombasal State

Solid

Thrombasal LogP

2.917

Thrombasal Dosage Forms

Tablet

Thrombasal Indication

For the treatment of pulmonary embolism, cardiomyopathy, atrial fibrillation and flutter, cerebral embolism, mural thrombosis, and thrombophili. Also used for anticoagulant prophylaxis.

Thrombasal Pharmacology

Phenindione thins the blood by antagonizing vitamin K which is required for the production of clotting factors in the liver. Anticoagulants such as Phenindione have no direct effect on an established thrombus, nor do they reverse ischemic tissue damage (damage caused by an inadequate blood supply to an organ or part of the body). However, once a thrombus has occurred, the goal of anticoagulant treatment is to prevent further extension of the formed clot and prevent secondary thromboembolic complications which may result in serious and possibly fatal sequelae. Phenindione has actions similar to warfarin, but it is now rarely employed because of its higer incidence of severe adverse effects.

Thrombasal Absorption

Absorbed slowly from the gastrointestinal tract.

Thrombasal side effects and Toxicity

Oral, mouse: LD50 = 175 mg/kg; Oral, rat: LD50 = 163 mg/kg.

Thrombasal Patient Information

No information avaliable

Thrombasal Organisms Affected

Humans and other mammals