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Metizol
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Metizol Brand names, Metizol Analogs

Metizol Brand Names Mixture

  • No information avaliable

Metizol Chemical_Formula

C4H6N2S

Metizol RX_link

http://www.rxlist.com/cgi/generic3/methim.htm

Metizol fda sheet

Metizol msds (material safety sheet)

Metizol MSDS

Metizol Synthesis Reference

No information avaliable

Metizol Molecular Weight

114.17 g/mol

Metizol Melting Point

146 oC

Metizol H2O Solubility

275 g/L

Metizol State

Solid

Metizol LogP

-0.34

Metizol Dosage Forms

Tablet (5 or 10 mg)

Metizol Indication

For the treatment of hyperthyroidism, goiter, Graves disease and psoriasis.

Metizol Pharmacology

Used in the treatment of hyperthyroidism or an overactive thyroid gland, methimazole inhibits the synthesis of thyroid hormones and thus is effective in the treatment of hyperthyroidism. It may also be used to ameliorate hyperthyroidism in preparation for subtotal thyroidectomy or radioactive iodine therapy.

Metizol Absorption

Rapid with an oral bioavailability of 93%.

Metizol side effects and Toxicity

Oral LD50 in rats is 2250 mg/kg. Symptoms of overdose include nausea, vomiting, epigastric distress, headache, fever, joint pain, pruritus, and edema. Aplastic anemia (pancy-topenia) or agranulocytosis may be manifested in hours to days. Less frequent events are hepatitis, nephrotic syndrome, exfoliative dermatitis, neuropathies, and CNS stimulation or depression.

Metizol Patient Information

Patients should be instructed to report to their physicians any symptoms of agranulocytosis, such as fever or sore throat.

Metizol Organisms Affected

Humans and other mammals