Merkastan
Merkastan Brand names, Merkastan Analogs
- Basolan
- Danantizol
- Favistan
- Frentirox
- Mercaptazole
- Mercasolyl
- Mercazole
- Mercazolyl
- Merkastan
- Merkazolil
- Metazolo
- Methamazole
- Methiamazole
- Methimazol
- Methylmercaptoimidazole
- Metizol
- Metothyrin
- Metothyrine
- Metotirin
- Propyl-Thyracil
- Strumazol
- Strumazole
- Tapazole
- Tapuzole
- Thacapzol
- Thiamazol
- Thiamazole
- Thimazole
- Thycapsol
- Thycapzol
- Thymidazol
- Thymidazole
- USAF EL-30
Merkastan Brand Names Mixture
- No information avaliable
Merkastan Chemical_Formula
C4H6N2S
Merkastan RX_link
http://www.rxlist.com/cgi/generic3/methim.htm
Merkastan fda sheet
Merkastan msds (material safety sheet)
Merkastan Synthesis Reference
No information avaliable
Merkastan Molecular Weight
114.17 g/mol
Merkastan Melting Point
146 oC
Merkastan H2O Solubility
275 g/L
Merkastan State
Solid
Merkastan LogP
-0.34
Merkastan Dosage Forms
Tablet (5 or 10 mg)
Merkastan Indication
For the treatment of hyperthyroidism, goiter, Graves disease and psoriasis.
Merkastan Pharmacology
Used in the treatment of hyperthyroidism or an overactive thyroid gland, methimazole inhibits the synthesis of thyroid hormones and thus is effective in the treatment of hyperthyroidism. It may also be used to ameliorate hyperthyroidism in preparation for subtotal thyroidectomy or radioactive iodine therapy.
Merkastan Absorption
Rapid with an oral bioavailability of 93%.
Merkastan side effects and Toxicity
Oral LD50 in rats is 2250 mg/kg. Symptoms of overdose include nausea, vomiting, epigastric distress, headache, fever, joint pain, pruritus, and edema. Aplastic anemia (pancy-topenia) or agranulocytosis may be manifested in hours to days. Less frequent events are hepatitis, nephrotic syndrome, exfoliative dermatitis, neuropathies, and CNS stimulation or depression.
Merkastan Patient Information
Patients should be instructed to report to their physicians any symptoms of agranulocytosis, such as fever or sore throat.
Merkastan Organisms Affected
Humans and other mammals
