Methamazole en es it fr

Methamazole Brand names, Methamazole Analogs

Methamazole Brand Names Mixture

  • No information avaliable

Methamazole Chemical_Formula

C4H6N2S

Methamazole RX_link

http://www.rxlist.com/cgi/generic3/methim.htm

Methamazole fda sheet

Methamazole msds (material safety sheet)

Methamazole MSDS

Methamazole Synthesis Reference

No information avaliable

Methamazole Molecular Weight

114.17 g/mol

Methamazole Melting Point

146 oC

Methamazole H2O Solubility

275 g/L

Methamazole State

Solid

Methamazole LogP

-0.34

Methamazole Dosage Forms

Tablet (5 or 10 mg)

Methamazole Indication

For the treatment of hyperthyroidism, goiter, Graves disease and psoriasis.

Methamazole Pharmacology

Used in the treatment of hyperthyroidism or an overactive thyroid gland, methimazole inhibits the synthesis of thyroid hormones and thus is effective in the treatment of hyperthyroidism. It may also be used to ameliorate hyperthyroidism in preparation for subtotal thyroidectomy or radioactive iodine therapy.

Methamazole Absorption

Rapid with an oral bioavailability of 93%.

Methamazole side effects and Toxicity

Oral LD50 in rats is 2250 mg/kg. Symptoms of overdose include nausea, vomiting, epigastric distress, headache, fever, joint pain, pruritus, and edema. Aplastic anemia (pancy-topenia) or agranulocytosis may be manifested in hours to days. Less frequent events are hepatitis, nephrotic syndrome, exfoliative dermatitis, neuropathies, and CNS stimulation or depression.

Methamazole Patient Information

Patients should be instructed to report to their physicians any symptoms of agranulocytosis, such as fever or sore throat.

Methamazole Organisms Affected

Humans and other mammals