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Thiamazol
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Thiamazol Brand names, Thiamazol Analogs

Thiamazol Brand Names Mixture

  • No information avaliable

Thiamazol Chemical_Formula

C4H6N2S

Thiamazol RX_link

http://www.rxlist.com/cgi/generic3/methim.htm

Thiamazol fda sheet

Thiamazol msds (material safety sheet)

Thiamazol MSDS

Thiamazol Synthesis Reference

No information avaliable

Thiamazol Molecular Weight

114.17 g/mol

Thiamazol Melting Point

146 oC

Thiamazol H2O Solubility

275 g/L

Thiamazol State

Solid

Thiamazol LogP

-0.34

Thiamazol Dosage Forms

Tablet (5 or 10 mg)

Thiamazol Indication

For the treatment of hyperthyroidism, goiter, Graves disease and psoriasis.

Thiamazol Pharmacology

Used in the treatment of hyperthyroidism or an overactive thyroid gland, methimazole inhibits the synthesis of thyroid hormones and thus is effective in the treatment of hyperthyroidism. It may also be used to ameliorate hyperthyroidism in preparation for subtotal thyroidectomy or radioactive iodine therapy.

Thiamazol Absorption

Rapid with an oral bioavailability of 93%.

Thiamazol side effects and Toxicity

Oral LD50 in rats is 2250 mg/kg. Symptoms of overdose include nausea, vomiting, epigastric distress, headache, fever, joint pain, pruritus, and edema. Aplastic anemia (pancy-topenia) or agranulocytosis may be manifested in hours to days. Less frequent events are hepatitis, nephrotic syndrome, exfoliative dermatitis, neuropathies, and CNS stimulation or depression.

Thiamazol Patient Information

Patients should be instructed to report to their physicians any symptoms of agranulocytosis, such as fever or sore throat.

Thiamazol Organisms Affected

Humans and other mammals