Mercazolyl

Mercazolyl Brand names, Mercazolyl Analogs

Mercazolyl Brand Names Mixture

No information avaliable

Mercazolyl Chemical_Formula

C₄H₆N₂S

Mercazolyl RX_link

http://www.rxlist.com/cgi/generic3/methim.htm

Mercazolyl fda sheet

Mercazolyl msds (material safety sheet)

Mercazolyl MSDS

Mercazolyl Synthesis Reference

No information avaliable

Mercazolyl Molecular Weight

114.17 g/mol

Mercazolyl Melting Point

146 ^oC

Mercazolyl H₂O Solubility

275 g/L

Mercazolyl State

Solid

Mercazolyl LogP

-0.34

Mercazolyl Dosage Forms

Tablet (5 or 10 mg)

Mercazolyl Indication

For the treatment of hyperthyroidism, goiter, Graves disease and psoriasis.

Mercazolyl Pharmacology

Used in the treatment of hyperthyroidism or an overactive thyroid gland, methimazole inhibits the synthesis of thyroid hormones and thus is effective in the treatment of hyperthyroidism. It may also be used to ameliorate hyperthyroidism in preparation for subtotal thyroidectomy or radioactive iodine therapy.

Mercazolyl Absorption

Rapid with an oral bioavailability of 93%.

Mercazolyl side effects and Toxicity

Oral LD₅₀ in rats is 2250 mg/kg. Symptoms of overdose include nausea, vomiting, epigastric distress, headache, fever, joint pain, pruritus, and edema. Aplastic anemia (pancy-topenia) or agranulocytosis may be manifested in hours to days. Less frequent events are hepatitis, nephrotic syndrome, exfoliative dermatitis, neuropathies, and CNS stimulation or depression.

Mercazolyl Patient Information

Patients should be instructed to report to their physicians any symptoms of agranulocytosis, such as fever or sore throat.

Mercazolyl Organisms Affected

Humans and other mammals