Isofosfamide

Category

Isofosfamide




Useful info

Isofosfamide Brand names, Isofosfamide Analogs

Isofosfamide Brand Names Mixture

  • No information avaliable

    • Isofosfamide Chemical_Formula

    C7H15Cl2N2O2P

    Isofosfamide RX_link

    http://www.rxlist.com/cgi/generic2/ifosfamide.htm

    Isofosfamide fda sheet

    http://www.accessdata.fda.gov/scripts/cder/onctools/summary.cfm?ID=95

    Isofosfamide msds (material safety sheet)

    Isofosfamide MSDS

    Isofosfamide Synthesis Reference

    No information avaliable

    Isofosfamide Molecular Weight

    261.085 g/mol

    Isofosfamide Melting Point

    39-41 oC

    Isofosfamide H2O Solubility

    3780 mg/L

    Isofosfamide State

    Solid

    Isofosfamide LogP

    -0.01

    Isofosfamide Dosage Forms

    Powder for constitution and administration by intravenous infusion

    Isofosfamide Indication

    For third line chemotherapy of germ cell testicular cancer. It should ordinarily be used in combination with a prophylactic agent for hemorrhagic cystitis, such as mesna.

    Isofosfamide Pharmacology

    Ifosfamide selectively inhibits the synthesis of deoxyribonucleic acid (DNA). The guanine and cytosine content correlates with the degree of ifosfamide-induced cross-linking. At high concentrations of the drug, cellular RNA and protein synthesis are also suppressed.

    Isofosfamide Absorption

    No information avaliable

    Isofosfamide Toxicity

    LD50 (mouse) = 390-1005 mg/kg, LD50 (rat) = 150-190 mg/kg. Side effects include nausea, vomiting and myelosuppression. Toxic effects include central nervous system toxicity (confusion, hallucinations) and urotoxic effects (cystitis, blood in urine).

    Isofosfamide Patient Information

    No information avaliable

    Isofosfamide Organisms Affected

    Humans and other mammals