Iphosphamide

Category

Iphosphamide




Useful info

Iphosphamide Brand names, Iphosphamide Analogs

Iphosphamide Brand Names Mixture

  • No information avaliable

    • Iphosphamide Chemical_Formula

    C7H15Cl2N2O2P

    Iphosphamide RX_link

    http://www.rxlist.com/cgi/generic2/ifosfamide.htm

    Iphosphamide fda sheet

    http://www.accessdata.fda.gov/scripts/cder/onctools/summary.cfm?ID=95

    Iphosphamide msds (material safety sheet)

    Iphosphamide MSDS

    Iphosphamide Synthesis Reference

    No information avaliable

    Iphosphamide Molecular Weight

    261.085 g/mol

    Iphosphamide Melting Point

    39-41 oC

    Iphosphamide H2O Solubility

    3780 mg/L

    Iphosphamide State

    Solid

    Iphosphamide LogP

    -0.01

    Iphosphamide Dosage Forms

    Powder for constitution and administration by intravenous infusion

    Iphosphamide Indication

    For third line chemotherapy of germ cell testicular cancer. It should ordinarily be used in combination with a prophylactic agent for hemorrhagic cystitis, such as mesna.

    Iphosphamide Pharmacology

    Ifosfamide selectively inhibits the synthesis of deoxyribonucleic acid (DNA). The guanine and cytosine content correlates with the degree of ifosfamide-induced cross-linking. At high concentrations of the drug, cellular RNA and protein synthesis are also suppressed.

    Iphosphamide Absorption

    No information avaliable

    Iphosphamide Toxicity

    LD50 (mouse) = 390-1005 mg/kg, LD50 (rat) = 150-190 mg/kg. Side effects include nausea, vomiting and myelosuppression. Toxic effects include central nervous system toxicity (confusion, hallucinations) and urotoxic effects (cystitis, blood in urine).

    Iphosphamide Patient Information

    No information avaliable

    Iphosphamide Organisms Affected

    Humans and other mammals