Iphosphamide
Iphosphamide Brand names, Iphosphamide Analogs
Iphosphamide Brand Names Mixture
- No information avaliable
Iphosphamide Chemical_Formula
C7H15Cl2N2O2P
Iphosphamide RX_link
http://www.rxlist.com/cgi/generic2/ifosfamide.htm
Iphosphamide fda sheet
Iphosphamide msds (material safety sheet)
Iphosphamide Synthesis Reference
No information avaliable
Iphosphamide Molecular Weight
261.085 g/mol
Iphosphamide Melting Point
39-41 oC
Iphosphamide H2O Solubility
3780 mg/L
Iphosphamide State
Solid
Iphosphamide LogP
-0.01
Iphosphamide Dosage Forms
Powder for constitution and administration by intravenous infusion
Iphosphamide Indication
For third line chemotherapy of germ cell testicular cancer. It should ordinarily be used in combination with a prophylactic agent for hemorrhagic cystitis, such as mesna.
Iphosphamide Pharmacology
Ifosfamide selectively inhibits the synthesis of deoxyribonucleic acid (DNA). The guanine and cytosine content correlates with the degree of ifosfamide-induced cross-linking. At high concentrations of the drug, cellular RNA and protein synthesis are also suppressed.
Iphosphamide Absorption
No information avaliable
Iphosphamide side effects and Toxicity
LD50 (mouse) = 390-1005 mg/kg, LD50 (rat) = 150-190 mg/kg. Side effects include nausea, vomiting and myelosuppression. Toxic effects include central nervous system toxicity (confusion, hallucinations) and urotoxic effects (cystitis, blood in urine).
Iphosphamide Patient Information
No information avaliable
Iphosphamide Organisms Affected
Humans and other mammals
