IFEX

Category

IFEX




Useful info

IFEX Brand names, IFEX Analogs

IFEX Brand Names Mixture

  • No information avaliable

    • IFEX Chemical_Formula

    C7H15Cl2N2O2P

    IFEX RX_link

    http://www.rxlist.com/cgi/generic2/ifosfamide.htm

    IFEX fda sheet

    http://www.accessdata.fda.gov/scripts/cder/onctools/summary.cfm?ID=95

    IFEX msds (material safety sheet)

    IFEX MSDS

    IFEX Synthesis Reference

    No information avaliable

    IFEX Molecular Weight

    261.085 g/mol

    IFEX Melting Point

    39-41 oC

    IFEX H2O Solubility

    3780 mg/L

    IFEX State

    Solid

    IFEX LogP

    -0.01

    IFEX Dosage Forms

    Powder for constitution and administration by intravenous infusion

    IFEX Indication

    For third line chemotherapy of germ cell testicular cancer. It should ordinarily be used in combination with a prophylactic agent for hemorrhagic cystitis, such as mesna.

    IFEX Pharmacology

    Ifosfamide selectively inhibits the synthesis of deoxyribonucleic acid (DNA). The guanine and cytosine content correlates with the degree of ifosfamide-induced cross-linking. At high concentrations of the drug, cellular RNA and protein synthesis are also suppressed.

    IFEX Absorption

    No information avaliable

    IFEX Toxicity

    LD50 (mouse) = 390-1005 mg/kg, LD50 (rat) = 150-190 mg/kg. Side effects include nausea, vomiting and myelosuppression. Toxic effects include central nervous system toxicity (confusion, hallucinations) and urotoxic effects (cystitis, blood in urine).

    IFEX Patient Information

    No information avaliable

    IFEX Organisms Affected

    Humans and other mammals