Ifosfamide_Sterile

Category

Ifosfamide_Sterile




Useful info

Ifosfamide_Sterile Brand names, Ifosfamide_Sterile Analogs

Ifosfamide_Sterile Brand Names Mixture

  • No information avaliable

    • Ifosfamide_Sterile Chemical_Formula

    C7H15Cl2N2O2P

    Ifosfamide_Sterile RX_link

    http://www.rxlist.com/cgi/generic2/ifosfamide.htm

    Ifosfamide_Sterile fda sheet

    http://www.accessdata.fda.gov/scripts/cder/onctools/summary.cfm?ID=95

    Ifosfamide_Sterile msds (material safety sheet)

    Ifosfamide_Sterile MSDS

    Ifosfamide_Sterile Synthesis Reference

    No information avaliable

    Ifosfamide_Sterile Molecular Weight

    261.085 g/mol

    Ifosfamide_Sterile Melting Point

    39-41 oC

    Ifosfamide_Sterile H2O Solubility

    3780 mg/L

    Ifosfamide_Sterile State

    Solid

    Ifosfamide_Sterile LogP

    -0.01

    Ifosfamide_Sterile Dosage Forms

    Powder for constitution and administration by intravenous infusion

    Ifosfamide_Sterile Indication

    For third line chemotherapy of germ cell testicular cancer. It should ordinarily be used in combination with a prophylactic agent for hemorrhagic cystitis, such as mesna.

    Ifosfamide_Sterile Pharmacology

    Ifosfamide selectively inhibits the synthesis of deoxyribonucleic acid (DNA). The guanine and cytosine content correlates with the degree of ifosfamide-induced cross-linking. At high concentrations of the drug, cellular RNA and protein synthesis are also suppressed.

    Ifosfamide_Sterile Absorption

    No information avaliable

    Ifosfamide_Sterile Toxicity

    LD50 (mouse) = 390-1005 mg/kg, LD50 (rat) = 150-190 mg/kg. Side effects include nausea, vomiting and myelosuppression. Toxic effects include central nervous system toxicity (confusion, hallucinations) and urotoxic effects (cystitis, blood in urine).

    Ifosfamide_Sterile Patient Information

    No information avaliable

    Ifosfamide_Sterile Organisms Affected

    Humans and other mammals