Isoendoxan

Category

Isoendoxan




Useful info

Isoendoxan Brand names, Isoendoxan Analogs

Isoendoxan Brand Names Mixture

  • No information avaliable

    • Isoendoxan Chemical_Formula

    C7H15Cl2N2O2P

    Isoendoxan RX_link

    http://www.rxlist.com/cgi/generic2/ifosfamide.htm

    Isoendoxan fda sheet

    http://www.accessdata.fda.gov/scripts/cder/onctools/summary.cfm?ID=95

    Isoendoxan msds (material safety sheet)

    Isoendoxan MSDS

    Isoendoxan Synthesis Reference

    No information avaliable

    Isoendoxan Molecular Weight

    261.085 g/mol

    Isoendoxan Melting Point

    39-41 oC

    Isoendoxan H2O Solubility

    3780 mg/L

    Isoendoxan State

    Solid

    Isoendoxan LogP

    -0.01

    Isoendoxan Dosage Forms

    Powder for constitution and administration by intravenous infusion

    Isoendoxan Indication

    For third line chemotherapy of germ cell testicular cancer. It should ordinarily be used in combination with a prophylactic agent for hemorrhagic cystitis, such as mesna.

    Isoendoxan Pharmacology

    Ifosfamide selectively inhibits the synthesis of deoxyribonucleic acid (DNA). The guanine and cytosine content correlates with the degree of ifosfamide-induced cross-linking. At high concentrations of the drug, cellular RNA and protein synthesis are also suppressed.

    Isoendoxan Absorption

    No information avaliable

    Isoendoxan Toxicity

    LD50 (mouse) = 390-1005 mg/kg, LD50 (rat) = 150-190 mg/kg. Side effects include nausea, vomiting and myelosuppression. Toxic effects include central nervous system toxicity (confusion, hallucinations) and urotoxic effects (cystitis, blood in urine).

    Isoendoxan Patient Information

    No information avaliable

    Isoendoxan Organisms Affected

    Humans and other mammals