Iphosphamid

Category

Iphosphamid




Useful info

Iphosphamid Brand names, Iphosphamid Analogs

Iphosphamid Brand Names Mixture

  • No information avaliable

    • Iphosphamid Chemical_Formula

    C7H15Cl2N2O2P

    Iphosphamid RX_link

    http://www.rxlist.com/cgi/generic2/ifosfamide.htm

    Iphosphamid fda sheet

    http://www.accessdata.fda.gov/scripts/cder/onctools/summary.cfm?ID=95

    Iphosphamid msds (material safety sheet)

    Iphosphamid MSDS

    Iphosphamid Synthesis Reference

    No information avaliable

    Iphosphamid Molecular Weight

    261.085 g/mol

    Iphosphamid Melting Point

    39-41 oC

    Iphosphamid H2O Solubility

    3780 mg/L

    Iphosphamid State

    Solid

    Iphosphamid LogP

    -0.01

    Iphosphamid Dosage Forms

    Powder for constitution and administration by intravenous infusion

    Iphosphamid Indication

    For third line chemotherapy of germ cell testicular cancer. It should ordinarily be used in combination with a prophylactic agent for hemorrhagic cystitis, such as mesna.

    Iphosphamid Pharmacology

    Ifosfamide selectively inhibits the synthesis of deoxyribonucleic acid (DNA). The guanine and cytosine content correlates with the degree of ifosfamide-induced cross-linking. At high concentrations of the drug, cellular RNA and protein synthesis are also suppressed.

    Iphosphamid Absorption

    No information avaliable

    Iphosphamid Toxicity

    LD50 (mouse) = 390-1005 mg/kg, LD50 (rat) = 150-190 mg/kg. Side effects include nausea, vomiting and myelosuppression. Toxic effects include central nervous system toxicity (confusion, hallucinations) and urotoxic effects (cystitis, blood in urine).

    Iphosphamid Patient Information

    No information avaliable

    Iphosphamid Organisms Affected

    Humans and other mammals