Holoxan_1000

Category

Holoxan_1000




Useful info

Holoxan_1000 Brand names, Holoxan_1000 Analogs

Holoxan_1000 Brand Names Mixture

  • No information avaliable

    • Holoxan_1000 Chemical_Formula

    C7H15Cl2N2O2P

    Holoxan_1000 RX_link

    http://www.rxlist.com/cgi/generic2/ifosfamide.htm

    Holoxan_1000 fda sheet

    http://www.accessdata.fda.gov/scripts/cder/onctools/summary.cfm?ID=95

    Holoxan_1000 msds (material safety sheet)

    Holoxan_1000 MSDS

    Holoxan_1000 Synthesis Reference

    No information avaliable

    Holoxan_1000 Molecular Weight

    261.085 g/mol

    Holoxan_1000 Melting Point

    39-41 oC

    Holoxan_1000 H2O Solubility

    3780 mg/L

    Holoxan_1000 State

    Solid

    Holoxan_1000 LogP

    -0.01

    Holoxan_1000 Dosage Forms

    Powder for constitution and administration by intravenous infusion

    Holoxan_1000 Indication

    For third line chemotherapy of germ cell testicular cancer. It should ordinarily be used in combination with a prophylactic agent for hemorrhagic cystitis, such as mesna.

    Holoxan_1000 Pharmacology

    Ifosfamide selectively inhibits the synthesis of deoxyribonucleic acid (DNA). The guanine and cytosine content correlates with the degree of ifosfamide-induced cross-linking. At high concentrations of the drug, cellular RNA and protein synthesis are also suppressed.

    Holoxan_1000 Absorption

    No information avaliable

    Holoxan_1000 Toxicity

    LD50 (mouse) = 390-1005 mg/kg, LD50 (rat) = 150-190 mg/kg. Side effects include nausea, vomiting and myelosuppression. Toxic effects include central nervous system toxicity (confusion, hallucinations) and urotoxic effects (cystitis, blood in urine).

    Holoxan_1000 Patient Information

    No information avaliable

    Holoxan_1000 Organisms Affected

    Humans and other mammals