Ifsofamide

Category

Ifsofamide




Useful info

Ifsofamide Brand names, Ifsofamide Analogs

Ifsofamide Brand Names Mixture

  • No information avaliable

    • Ifsofamide Chemical_Formula

    C7H15Cl2N2O2P

    Ifsofamide RX_link

    http://www.rxlist.com/cgi/generic2/ifosfamide.htm

    Ifsofamide fda sheet

    http://www.accessdata.fda.gov/scripts/cder/onctools/summary.cfm?ID=95

    Ifsofamide msds (material safety sheet)

    Ifsofamide MSDS

    Ifsofamide Synthesis Reference

    No information avaliable

    Ifsofamide Molecular Weight

    261.085 g/mol

    Ifsofamide Melting Point

    39-41 oC

    Ifsofamide H2O Solubility

    3780 mg/L

    Ifsofamide State

    Solid

    Ifsofamide LogP

    -0.01

    Ifsofamide Dosage Forms

    Powder for constitution and administration by intravenous infusion

    Ifsofamide Indication

    For third line chemotherapy of germ cell testicular cancer. It should ordinarily be used in combination with a prophylactic agent for hemorrhagic cystitis, such as mesna.

    Ifsofamide Pharmacology

    Ifosfamide selectively inhibits the synthesis of deoxyribonucleic acid (DNA). The guanine and cytosine content correlates with the degree of ifosfamide-induced cross-linking. At high concentrations of the drug, cellular RNA and protein synthesis are also suppressed.

    Ifsofamide Absorption

    No information avaliable

    Ifsofamide Toxicity

    LD50 (mouse) = 390-1005 mg/kg, LD50 (rat) = 150-190 mg/kg. Side effects include nausea, vomiting and myelosuppression. Toxic effects include central nervous system toxicity (confusion, hallucinations) and urotoxic effects (cystitis, blood in urine).

    Ifsofamide Patient Information

    No information avaliable

    Ifsofamide Organisms Affected

    Humans and other mammals