Ifosfamid

Category

Ifosfamid




Useful info

Ifosfamid Brand names, Ifosfamid Analogs

Ifosfamid Brand Names Mixture

  • No information avaliable

    • Ifosfamid Chemical_Formula

    C7H15Cl2N2O2P

    Ifosfamid RX_link

    http://www.rxlist.com/cgi/generic2/ifosfamide.htm

    Ifosfamid fda sheet

    http://www.accessdata.fda.gov/scripts/cder/onctools/summary.cfm?ID=95

    Ifosfamid msds (material safety sheet)

    Ifosfamid MSDS

    Ifosfamid Synthesis Reference

    No information avaliable

    Ifosfamid Molecular Weight

    261.085 g/mol

    Ifosfamid Melting Point

    39-41 oC

    Ifosfamid H2O Solubility

    3780 mg/L

    Ifosfamid State

    Solid

    Ifosfamid LogP

    -0.01

    Ifosfamid Dosage Forms

    Powder for constitution and administration by intravenous infusion

    Ifosfamid Indication

    For third line chemotherapy of germ cell testicular cancer. It should ordinarily be used in combination with a prophylactic agent for hemorrhagic cystitis, such as mesna.

    Ifosfamid Pharmacology

    Ifosfamide selectively inhibits the synthesis of deoxyribonucleic acid (DNA). The guanine and cytosine content correlates with the degree of ifosfamide-induced cross-linking. At high concentrations of the drug, cellular RNA and protein synthesis are also suppressed.

    Ifosfamid Absorption

    No information avaliable

    Ifosfamid Toxicity

    LD50 (mouse) = 390-1005 mg/kg, LD50 (rat) = 150-190 mg/kg. Side effects include nausea, vomiting and myelosuppression. Toxic effects include central nervous system toxicity (confusion, hallucinations) and urotoxic effects (cystitis, blood in urine).

    Ifosfamid Patient Information

    No information avaliable

    Ifosfamid Organisms Affected

    Humans and other mammals