Ifosfamid
Ifosfamid Brand names, Ifosfamid Analogs
Ifosfamid Brand Names Mixture
- No information avaliable
Ifosfamid Chemical_Formula
C7H15Cl2N2O2P
Ifosfamid RX_link
http://www.rxlist.com/cgi/generic2/ifosfamide.htm
Ifosfamid fda sheet
Ifosfamid msds (material safety sheet)
Ifosfamid Synthesis Reference
No information avaliable
Ifosfamid Molecular Weight
261.085 g/mol
Ifosfamid Melting Point
39-41 oC
Ifosfamid H2O Solubility
3780 mg/L
Ifosfamid State
Solid
Ifosfamid LogP
-0.01
Ifosfamid Dosage Forms
Powder for constitution and administration by intravenous infusion
Ifosfamid Indication
For third line chemotherapy of germ cell testicular cancer. It should ordinarily be used in combination with a prophylactic agent for hemorrhagic cystitis, such as mesna.
Ifosfamid Pharmacology
Ifosfamide selectively inhibits the synthesis of deoxyribonucleic acid (DNA). The guanine and cytosine content correlates with the degree of ifosfamide-induced cross-linking. At high concentrations of the drug, cellular RNA and protein synthesis are also suppressed.
Ifosfamid Absorption
No information avaliable
Ifosfamid side effects and Toxicity
LD50 (mouse) = 390-1005 mg/kg, LD50 (rat) = 150-190 mg/kg. Side effects include nausea, vomiting and myelosuppression. Toxic effects include central nervous system toxicity (confusion, hallucinations) and urotoxic effects (cystitis, blood in urine).
Ifosfamid Patient Information
No information avaliable
Ifosfamid Organisms Affected
Humans and other mammals
