Isophosphamide

Category

Isophosphamide




Useful info

Isophosphamide Brand names, Isophosphamide Analogs

Isophosphamide Brand Names Mixture

  • No information avaliable

    • Isophosphamide Chemical_Formula

    C7H15Cl2N2O2P

    Isophosphamide RX_link

    http://www.rxlist.com/cgi/generic2/ifosfamide.htm

    Isophosphamide fda sheet

    http://www.accessdata.fda.gov/scripts/cder/onctools/summary.cfm?ID=95

    Isophosphamide msds (material safety sheet)

    Isophosphamide MSDS

    Isophosphamide Synthesis Reference

    No information avaliable

    Isophosphamide Molecular Weight

    261.085 g/mol

    Isophosphamide Melting Point

    39-41 oC

    Isophosphamide H2O Solubility

    3780 mg/L

    Isophosphamide State

    Solid

    Isophosphamide LogP

    -0.01

    Isophosphamide Dosage Forms

    Powder for constitution and administration by intravenous infusion

    Isophosphamide Indication

    For third line chemotherapy of germ cell testicular cancer. It should ordinarily be used in combination with a prophylactic agent for hemorrhagic cystitis, such as mesna.

    Isophosphamide Pharmacology

    Ifosfamide selectively inhibits the synthesis of deoxyribonucleic acid (DNA). The guanine and cytosine content correlates with the degree of ifosfamide-induced cross-linking. At high concentrations of the drug, cellular RNA and protein synthesis are also suppressed.

    Isophosphamide Absorption

    No information avaliable

    Isophosphamide Toxicity

    LD50 (mouse) = 390-1005 mg/kg, LD50 (rat) = 150-190 mg/kg. Side effects include nausea, vomiting and myelosuppression. Toxic effects include central nervous system toxicity (confusion, hallucinations) and urotoxic effects (cystitis, blood in urine).

    Isophosphamide Patient Information

    No information avaliable

    Isophosphamide Organisms Affected

    Humans and other mammals