Carbamyl Hydroxamate
Category
Carbamyl Hydroxamate Brand names, Carbamyl Hydroxamate Analogs
Carbamyl Hydroxamate Brand Names Mixture
Carbamyl Hydroxamate Chemical_Formula
CH4N2O2
Carbamyl Hydroxamate RX_link
http://www.rxlist.com/cgi/generic2/hydroxyurea.htm
Carbamyl Hydroxamate fda sheet
Carbamyl Hydroxamate msds (material safety sheet)
Carbamyl Hydroxamate Synthesis Reference
No information avaliable
Carbamyl Hydroxamate Molecular Weight
76.0547 g/mol
Carbamyl Hydroxamate Melting Point
142-146 oC
Carbamyl Hydroxamate H2O Solubility
1E+006 mg/L
Carbamyl Hydroxamate State
Solid
Carbamyl Hydroxamate LogP
-1.432
Carbamyl Hydroxamate Dosage Forms
Capsule
Carbamyl Hydroxamate Indication
For management of melanoma, resistant chronic myelocytic leukemia, and recurrent, metastatic, or inoperable carcinoma of the ovary and Sickle-cell anemia.
Carbamyl Hydroxamate Pharmacology
Hydroxyurea has dose-dependent synergistic activity with cisplatin in vitro. In vivo Hydroxyurea showed activity in combination with cisplatin against the LX-1 and CALU-6 human lung xenografts, but minimal activity was seen with the NCI-H460 or NCI-H520 xenografts. Hydroxyurea was synergistic with cisplatin in the Lewis lung murine xenograft. Sequential exposure to Hydroxyurea 4 hours before cisplatin produced the greatest interaction.
Carbamyl Hydroxamate Absorption
Well absorbed from the gastrointestinal tract.
Carbamyl Hydroxamate side effects and Toxicity
Oral, mouse: LD50 = 7330 mg/kg; Oral, rat: LD50 = 5760 mg/kg
Carbamyl Hydroxamate Patient Information
HYDREA is a medication that must be handled with care. People who are not taking HYDREA should not be
exposed to it. If the powder from the capsule is spilled, it should be wiped up immediately with a damp disposable
towel and discarded in a closed container, such as a plastic bag. The medication should be kept away from children
and pets.
Carbamyl Hydroxamate Organisms Affected
Humans and other mammals
