Hydroxylurea Brand names, Hydroxylurea Analogs
Hydroxylurea Brand Names Mixture
Hydroxylurea fda sheet
Hydroxylurea msds (material safety sheet)
Hydroxylurea Synthesis Reference
No information avaliable
Hydroxylurea Molecular Weight
Hydroxylurea Melting Point
Hydroxylurea H2O Solubility
Hydroxylurea Dosage Forms
For management of melanoma, resistant chronic myelocytic leukemia, and recurrent, metastatic, or inoperable carcinoma of the ovary and Sickle-cell anemia.
Hydroxyurea has dose-dependent synergistic activity with cisplatin in vitro. In vivo Hydroxyurea showed activity in combination with cisplatin against the LX-1 and CALU-6 human lung xenografts, but minimal activity was seen with the NCI-H460 or NCI-H520 xenografts. Hydroxyurea was synergistic with cisplatin in the Lewis lung murine xenograft. Sequential exposure to Hydroxyurea 4 hours before cisplatin produced the greatest interaction.
Well absorbed from the gastrointestinal tract.
Hydroxylurea side effects and Toxicity
Oral, mouse: LD50 = 7330 mg/kg; Oral, rat: LD50 = 5760 mg/kg
Hydroxylurea Patient Information
HYDREA is a medication that must be handled with care. People who are not taking HYDREA should not be
exposed to it. If the powder from the capsule is spilled, it should be wiped up immediately with a damp disposable
towel and discarded in a closed container, such as a plastic bag. The medication should be kept away from children
Hydroxylurea Organisms Affected
Humans and other mammals