Hydroxylurea
Category
Hydroxylurea Brand names, Hydroxylurea Analogs
Hydroxylurea Brand Names Mixture
Hydroxylurea Chemical_Formula
CH4N2O2
Hydroxylurea RX_link
http://www.rxlist.com/cgi/generic2/hydroxyurea.htm
Hydroxylurea fda sheet
Hydroxylurea msds (material safety sheet)
Hydroxylurea Synthesis Reference
No information avaliable
Hydroxylurea Molecular Weight
76.0547 g/mol
Hydroxylurea Melting Point
142-146 oC
Hydroxylurea H2O Solubility
1E+006 mg/L
Hydroxylurea State
Solid
Hydroxylurea LogP
-1.432
Hydroxylurea Dosage Forms
Capsule
Hydroxylurea Indication
For management of melanoma, resistant chronic myelocytic leukemia, and recurrent, metastatic, or inoperable carcinoma of the ovary and Sickle-cell anemia.
Hydroxylurea Pharmacology
Hydroxyurea has dose-dependent synergistic activity with cisplatin in vitro. In vivo Hydroxyurea showed activity in combination with cisplatin against the LX-1 and CALU-6 human lung xenografts, but minimal activity was seen with the NCI-H460 or NCI-H520 xenografts. Hydroxyurea was synergistic with cisplatin in the Lewis lung murine xenograft. Sequential exposure to Hydroxyurea 4 hours before cisplatin produced the greatest interaction.
Hydroxylurea Absorption
Well absorbed from the gastrointestinal tract.
Hydroxylurea side effects and Toxicity
Oral, mouse: LD50 = 7330 mg/kg; Oral, rat: LD50 = 5760 mg/kg
Hydroxylurea Patient Information
HYDREA is a medication that must be handled with care. People who are not taking HYDREA should not be
exposed to it. If the powder from the capsule is spilled, it should be wiped up immediately with a damp disposable
towel and discarded in a closed container, such as a plastic bag. The medication should be kept away from children
and pets.
Hydroxylurea Organisms Affected
Humans and other mammals
