Hydroxycarbamide
Category
Hydroxycarbamide Brand names, Hydroxycarbamide Analogs
Hydroxycarbamide Brand Names Mixture
Hydroxycarbamide Chemical_Formula
CH4N2O2
Hydroxycarbamide RX_link
http://www.rxlist.com/cgi/generic2/hydroxyurea.htm
Hydroxycarbamide fda sheet
Hydroxycarbamide msds (material safety sheet)
Hydroxycarbamide Synthesis Reference
No information avaliable
Hydroxycarbamide Molecular Weight
76.0547 g/mol
Hydroxycarbamide Melting Point
142-146 oC
Hydroxycarbamide H2O Solubility
1E+006 mg/L
Hydroxycarbamide State
Solid
Hydroxycarbamide LogP
-1.432
Hydroxycarbamide Dosage Forms
Capsule
Hydroxycarbamide Indication
For management of melanoma, resistant chronic myelocytic leukemia, and recurrent, metastatic, or inoperable carcinoma of the ovary and Sickle-cell anemia.
Hydroxycarbamide Pharmacology
Hydroxyurea has dose-dependent synergistic activity with cisplatin in vitro. In vivo Hydroxyurea showed activity in combination with cisplatin against the LX-1 and CALU-6 human lung xenografts, but minimal activity was seen with the NCI-H460 or NCI-H520 xenografts. Hydroxyurea was synergistic with cisplatin in the Lewis lung murine xenograft. Sequential exposure to Hydroxyurea 4 hours before cisplatin produced the greatest interaction.
Hydroxycarbamide Absorption
Well absorbed from the gastrointestinal tract.
Hydroxycarbamide side effects and Toxicity
Oral, mouse: LD50 = 7330 mg/kg; Oral, rat: LD50 = 5760 mg/kg
Hydroxycarbamide Patient Information
HYDREA is a medication that must be handled with care. People who are not taking HYDREA should not be
exposed to it. If the powder from the capsule is spilled, it should be wiped up immediately with a damp disposable
towel and discarded in a closed container, such as a plastic bag. The medication should be kept away from children
and pets.
Hydroxycarbamide Organisms Affected
Humans and other mammals
