Biosupressin
Category
Biosupressin Brand names, Biosupressin Analogs
Biosupressin Brand Names Mixture
Biosupressin Chemical_Formula
CH4N2O2
Biosupressin RX_link
http://www.rxlist.com/cgi/generic2/hydroxyurea.htm
Biosupressin fda sheet
Biosupressin msds (material safety sheet)
Biosupressin Synthesis Reference
No information avaliable
Biosupressin Molecular Weight
76.0547 g/mol
Biosupressin Melting Point
142-146 oC
Biosupressin H2O Solubility
1E+006 mg/L
Biosupressin State
Solid
Biosupressin LogP
-1.432
Biosupressin Dosage Forms
Capsule
Biosupressin Indication
For management of melanoma, resistant chronic myelocytic leukemia, and recurrent, metastatic, or inoperable carcinoma of the ovary and Sickle-cell anemia.
Biosupressin Pharmacology
Hydroxyurea has dose-dependent synergistic activity with cisplatin in vitro. In vivo Hydroxyurea showed activity in combination with cisplatin against the LX-1 and CALU-6 human lung xenografts, but minimal activity was seen with the NCI-H460 or NCI-H520 xenografts. Hydroxyurea was synergistic with cisplatin in the Lewis lung murine xenograft. Sequential exposure to Hydroxyurea 4 hours before cisplatin produced the greatest interaction.
Biosupressin Absorption
Well absorbed from the gastrointestinal tract.
Biosupressin side effects and Toxicity
Oral, mouse: LD50 = 7330 mg/kg; Oral, rat: LD50 = 5760 mg/kg
Biosupressin Patient Information
HYDREA is a medication that must be handled with care. People who are not taking HYDREA should not be
exposed to it. If the powder from the capsule is spilled, it should be wiped up immediately with a damp disposable
towel and discarded in a closed container, such as a plastic bag. The medication should be kept away from children
and pets.
Biosupressin Organisms Affected
Humans and other mammals
